Results 131 to 140 of about 5,145,453 (383)
Molecular Oncology, EarlyView.Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Organ Failure Due to Systemic Injury in Acute Pancreatitis.
Gastroenterology, 2019 Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure, which is seen in approximately 20% of all cases of acute pancreatitis and defines "severe acute pancreatitis." Organ ...
P. Garg, Vijay P. Singh
semanticscholar +1 more source
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
Multivariate Shortfall Risk Allocation and Systemic Risk
, 2017 The ongoing concern about systemic risk since the outburst of the global financial crisis has highlighted the need for risk measures at the level of sets of interconnected financial components, such as portfolios, institutions or members of clearing ...
Armenti, Yannick +3 more
core +1 more source
Hypernetworks for Policy Design in Systems of Systems of Systems [PDF]
, 2013 Hypernetworks generalise networks and hypergraphs, allowing relations between many things to be modelled by hypersimplices with richer structure than hypergraph edges. They provide a way of integrating bottom-up and top-down micro, meso and macrolevel dynamics in multilevel systems. They provide a natural way of representing social structures, enabling
openaire +2 more sources
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Retrovirology, 2006 Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology remains obscure.
J. Brenchley
semanticscholar +1 more source
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
MOUTH INFECTION AS A SOURCE OF SYSTEMIC DISEASE [PDF]
, 1914 Edward C. Rosenow
openalex +1 more source
The systemic mind and a conceptual framework for the psychosocial environment of business enterprises: Practical implications for systemic leadership training [PDF]
, 2015 This chapter introduces a research-based conceptual framework for the study of the inner psychosocial reality of business enterprises. It is called the Inner Organizational Ecosystem Approach (IOEA).
Parma, Petr, Trnka, Radek
core