Results 111 to 120 of about 4,275,878 (309)

The diagnostic utility of miRNA21 in systemic sclerosis

Reumatismo
Objective. Systemic sclerosis (SSc) is a multisystem autoimmune disease of heterogeneous pathogenesis, including vascular, immunologic, genetic, epigenetic, and environmental factors. Progressive fibrosis is the hallmark of SSc.
Gehad Gamal Maghraby, May Mohsen Tolba Fawzi, Laila Ahmed Rashed, Mohamed Tharwat Hegazy   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Systemic Haiku

Murmurations, 2017
Various Systemic Practitioners
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

LP-012 Patients with systemic lupus erythematosus and hyperproduction of antibodies to anti-U1RNP

Lupus Science and Medicine, 2023
Oxana Desinova, Olga Koneva, Rushana Shayakhmetova, Lidia Ananyeva, Liudmila Garzanova, Olga Ovsyannikova, Mayya Starovoytova   +6 more
doaj   +1 more source

A Comprehensive Review of Treatment Outcomes in Lichen Planus Pigmentosus

Clinical Dermatology Review
Lichen Planus Pigmentosus (LPP) has been a topic of debate and extensive research both with respect to its existence and its treatment. Many treatment options have evolved from topical to systemic each one emerging as an effective treatment in one or the
Rashmi Singh, Rajnish Kumar, Tulika Rai
doaj   +1 more source

Controlling Financial Chaos: The Power and Limits of Law [PDF]

, 2012
This Essay examines how law can help to control financial chaos. To that end, regulation should strive to not only maximize economic efficiency within the financial system but also protect the financial system itself.
Schwarcz, Steven L.
core   +1 more source

Systems thinking, systems doing [PDF]

Nature Food, 2020
openaire   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Enrico Castellani and the 1972-1973 experiments: grid, decentralisation and transparency in Lavagna and Topologema

piano b
The aim of the article is to investigate some works produced by Enrico Castellani in the early 1970s. In the light of the theoretical elaborations conceived by Castellani in the 1960s and during the following decades, the article aims to reread in ...
Michele Giuliano Cipolla
doaj   +1 more source