Results 91 to 100 of about 4,275,878 (309)
Ingeniare: Revista Chilena de Ingeniería, 2009 This article describes the use and application of a new methodology that has been developed for the conceptual design of new products, which emphasizes those innovating characteristics in design processes, thus fostering creative development.
Bernabé Hernandis Ortuño +1 more
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Markets, Systemic Risk, and the Subprime Mortgage Crisis [PDF]
, 2008 The recent subprime mortgage meltdown is undermining financial market stability and has the potential to cause a true systemic breakdown, collapsing the world\u27s financial systems like a row of dominoes.
Schwarcz, Steven L.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Rectal Ulcer Developed in Systemic Lupus Erythematosus without Ischemic Colitis
The Korean Journal of Gastroenterology, 2019 Rectal involvement by systemic lupus erythematosus (SLE) is quite rare. Approximately 14 cases have been reported worldwide, but only one with ischemic colitis has been reported in Korea.
Ki Chang Sohn +7 more
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Metabolic Adaptations in Cancer and the Host Using Drosophila Models and Advanced Tools
CellsCancer is a multifactorial process involving genetic, epigenetic, physiological, and metabolic changes. The ability of tumours to regulate new reactive pathways is essential for their survival. A key aspect of this involves the decision-making process of
Ernesto Saez-Carrion +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Drug Design, Development and Therapy, 2016 V Di Lernia,1 F Bardazzi2 1Dermatology Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, 2Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: The outlook for ...
Di Lernia V, Bardazzi F
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Social and Ecological Responsibility: A Critical Systemic Perspective [PDF]
, 2003 The notion of systemic thinking for social and ecological responsibility is deconstructed and its holistic potential examined from a critical systemic perspective informed by the ideas of the systems philosopher, C. West-Churchman.
Reynolds, Martin
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