Results 71 to 80 of about 2,206,550 (269)

Enabling Systems and the Adaptability of Complex Systems-of- Systems

Procedia Computer Science, 2012
AbstractFor complex techno-social system-of-systems, the system's robustness and its ability to adapt to changing environments and circumstances over the life cycle of the systems is an important measure of system quality and effectiveness.The IEEE 15288-2004 standard describes the concept of “enabling systems” that provide non-operational services to ...
Charles O. Adler, Cihan H. Dagli
openaire   +1 more source

Rectal Ulcer Developed in Systemic Lupus Erythematosus without Ischemic Colitis

The Korean Journal of Gastroenterology, 2019
Rectal involvement by systemic lupus erythematosus (SLE) is quite rare. Approximately 14 cases have been reported worldwide, but only one with ischemic colitis has been reported in Korea.
Ki Chang Sohn, Won Gak Heo, Min Su Chu, Eui Joong Kim, Jong Hyeok Chung, Suck Chei Choi, Ki Jung Yun, Geom Seog Seo   +7 more
doaj  

Metabolic Adaptations in Cancer and the Host Using Drosophila Models and Advanced Tools

Cells
Cancer is a multifactorial process involving genetic, epigenetic, physiological, and metabolic changes. The ability of tumours to regulate new reactive pathways is essential for their survival. A key aspect of this involves the decision-making process of
Ernesto Saez-Carrion, Mario Aguilar-Aragon, Lucia García-López, Maria Dominguez, Mary Luz Uribe   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

System-of-Systems Viewpoint for System Architecture Documentation

CoRR, 2018
Context: The systems comprising a system of systems (SoS) are inde- pendently acquired, operated, and managed. Frequently, the architecture documentation of these existing systems addresses only a stand-alone perspective, and must be augmented to address concerns that arise in the integrated SoS.
John Klein, Hans van Vliet
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis

Drug Design, Development and Therapy, 2016
V Di Lernia,1 F Bardazzi2 1Dermatology Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, 2Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: The outlook for ...
Di Lernia V, Bardazzi F
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Endogenous Nocardial Endophthalmitis Misdiagnosed as Giant Cell Arteritis

International Medical Case Reports Journal, 2020
Steven Gagnon,1– 3 Marc Saab1,2,4– 6 1Département d’ophtalmologie et d’oto-rhino-laryngologie – chirurgie cervico-faciale, Université Laval, Québec, QC, Canada; 2Hôpital Régional de Rimouski, Centre ...
Gagnon S, Saab M
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source