Results 61 to 70 of about 2,206,550 (269)
Modeling Information Systems as Systems of Systems. [PDF]
, 2018 Large industrial information systems are composed of dozens of inter-operating software applications. Each of them implements a relatively independent set of functions but also participates to business processes involving more applications. Applications may be COTS acquired from different vendors or custom-developed.
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Revista Brasileira de Ginecologia e Obstetrícia, 2011 OBJETIVOS: Conhecer a prevalência e alguns fatores associados ao baixo peso ao nascer entre gestantes adolescentes. MÉTODOS: Estudo de corte transversal, realizado entre outubro de 1994 a dezembro de 2009, com os partos ocorridos em uma maternidade de ...
Fernanda Garanhani Castro Surita +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2009 This article describes the use and application of a new methodology that has been developed for the conceptual design of new products, which emphasizes those innovating characteristics in design processes, thus fostering creative development.
Bernabé Hernandis Ortuño +1 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Security Assessment of Systems of Systems
2019 IEEE/ACM 7th International Workshop on Software Engineering for Systems-of-Systems (SESoS) and 13th Workshop on Distributed Software Development, Software Ecosystems and Systems-of-Systems (WDES), 2019 Engineering Systems of Systems is one of the new chal-lenges of the last few years. This depends on the increasing number of systems that must interact one with another to achieve a goal. One peculiarity of Systems of Systems is that they are made of systems able to live on their own with well-established functionalities and requirements, and that are ...
Miguel Angel Olivero +4 more
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BARRIERS TO LEARNING IN AN INCLUSIVE EDUCATION ENVIRONMENT, CAPRICORN DISTRICT, LIMPOPO PROVINCE [PDF]
Social Sciences and Education Research ReviewThis paper examines the ongoing barriers to learning within inclusive education environments, to promote equitable access and meaningful participation for all learners.
Marubini Christinah Sadiki +1 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source