Results 1 to 10 of about 64,045 (290)

Toxicity of Intravitreous Miconazole

Archives of Ophthalmology, 1982
Miconazole nitrate is a broad-spectrum antimycotic agent with low systemic and ocular toxicity. Since this drug does not adequately penetrate the vitreous cavity by topical, subconjunctival, or intravenous routes, we determined whether it can be given intravitreously for fungal endophthalmitis.
F I, Tolentino, C S, Foster, M, Lahav, L H, Liu, A R, Rabin   +4 more
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Communicating Intravitreal Cysticercosis

Ophthalmic Surgery, Lasers and Imaging Retina, 1989
ABSTRACT A viable intravitreal Cysticercus cellulosae communicating with subretinal space was identified in a 45year-old man. The cyst was removed in toto via the direct scleral approach without incident. To our knowledge this is the first report of intravitreal Cysticercus with subretinal extension removed successfully by the direct route ...
A, Kumar, L, Verma, P K, Khosla, H K, Tewari, S N, Jha   +4 more
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Toxicity of Intravitreal Interferon

Ophthalmic Surgery, Lasers and Imaging Retina, 1986
ABSTRACT We evaluated the toxicity of injecting human fibreblast Interferon intravitreally in rabbit eyes. A single intravitreal injection of 166,660 units/0.1 ml was nontoxic to ocular structures, as demonstrated by electroretinographic and histologie examination.
S, Vegh, G A, Peyman, J, Vernot, R, Fiscella   +3 more
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Toxicity of intravitreal oxiconazole

International Ophthalmology, 1989
Oxiconazole, a new imidazole derivative, has a broad antifungal spectrum in vitro and in vivo. Adult New Zealand white rabbits were injected intravitreally with doses ranging from 10 to 100 micrograms of this drug. Eyes were evaluated with preoperative and postoperative biomicroscopy and indirect ophthalmoscopy, electroretinography, and light ...
J A, Schulman, G A, Peyman, J, Dietlein, R, Fiscella   +3 more
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INTRAVITREAL TOXICITY OF GARENOXACIN

Retina, 2006
To assess the retinal toxicity of varying concentrations of intravitreally injected garenoxacin.Twenty eyes of 20 New Zealand albino rabbits were used for this study. The animals were anesthetized with ketamine (35-50 mg/kg) and xylazine (3-5 mg/kg).
Mohammad Riazi, Esfahani, Abdul Ahad, Kazi, Gholam A, Peyman, John T, Dellacroce, Erdinc, Aydin   +4 more
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INTRAVITREAL TOXICITY OF MOXIFLOXACIN

Retina, 2006
To assess the retinal toxicity of various concentrations of intravitreally administered moxifloxacin, a fourth-generation fluoroquinolone.Ten New Zealand albino rabbits were divided into five groups. The initial concentration of moxifloxacin (400 mg/250 mL) was titrated using 5% dextrose solution to concentrations (320 microg/0.1 mL, 160 microg/0.1 mL,
Erdinc, Aydin, Abdul Ahad, Kazi, Gholam A, Peyman, Mohammad Riazi, Esfahani   +3 more
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INTRAVITREAL USE OF STREPTOMYCIN

Archives of Ophthalmology, 1949
EXPERIMENTAL streptomycin in treatment of intraocular infections have been published.1 Since, as has been shown by Leopold and Nichols, 1a streptomycin penetrates poorly from the blood stream into the normal vitreous humor, systemic administration of the drug is inadequate in therapy of infections of the vitreous. In a more recent series of experiments,
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Intravitreal Injection of Piperacillin

Ophthalmic Surgery, Lasers and Imaging Retina, 1989
ABSTRACT Piperacillin was injected into the vitreous body of rabbit eyes to evaluate its suitability for intraocular injection and its toxicity on intraocular tissues. Doses ranged from 50 µg to 3,000 µg. Toxicity was determined through histology and electroretinograms by comparing the piperacillin-injected eyes with eyes injected with ...
H C, Semple, J C, Liu, G A, Peyman
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Intravitreal Toxicity of Cotrimoxazole

Ophthalmic Surgery, Lasers and Imaging Retina, 1988
ABSTRACT We investigated the intravitreal toxicity of cotrimoxazole (trimethoprim 80 mg and sulfamethoxazole 400 mg/5 ml of injection fluid) in albino rabbits. Eyes injected intravitreally with 1600 µg/0.1 cc (reported in trimethoprim concentration) exhibited no histologic or abnormal electroretinographic responses after 14 days. A vitrectomy
R, Fiscella, G A, Peyman, A, Kimura, G, Small   +3 more
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Experimental Intravitreal Gentamicin

American Journal of Ophthalmology, 1976
Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye.
I G, Zachary, R K, Forster
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