Results 11 to 20 of about 99,964 (316)

Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity: The FIREFLEYE Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance Laser photocoagulation, which is the standard treatment for retinopathy of prematurity (ROP), can have adverse events. Studies of anti-vascular endothelial growth factor injections have suggested efficacy in the treatment of ROP, but few ...
A. Stahl, E. Sukgen, Wei-Chi Wu, D. Lepore, H. Nakanishi, J. Mazela, D. Moshfeghi, R. Vitti, A. Athanikar, Karen W. Chu, Pablo Iveli, Fei Zhao, T. Schmelter, S. Leal, Evra Koefuencue, N. Azuma   +15 more
semanticscholar   +1 more source

The Role of Intravitreal Corticosteroids in the Treatment of DME: Predictive OCT Biomarkers

International Journal of Molecular Sciences, 2022
This work aims to summarize predictive biomarkers to guide treatment choice in DME. Intravitreal anti-VEGF is considered the gold standard treatment for centers involving DME, while intravitreal steroid treatment has been established as a second-line ...
M. Munk, G. Somfai, M. D. de Smet, G. Donati, M. Menke, J. Garweg, Lala Ceklic   +6 more
semanticscholar   +1 more source

Vitreous Humor: Composition, Characteristics and Implication on Intravitreal Drug Delivery

Current Eye Research, 2022
Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time.
Deepakkumar Mishra, Shilpkala Gade, Katie Glover, R. Sheshala, T. R. Singh   +4 more
semanticscholar   +1 more source

Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy

JAMA ophthalmology, 2021
Key Points Question Does treatment of moderately severe to severe nonproliferative diabetic retinopathy (NPDR) with intravitreal aflibercept injections result in 2-step or greater improvement on the Diabetic Retinopathy Severity Scale in more eyes, fewer
David M. Brown, C. Wykoff, D. Boyer, J. Heier, W. Clark, A. Emanuelli, Patrick M Higgins, M. Singer, D. Weinreich, G. Yancopoulos, Alyson J. Berliner, Karen W. Chu, Kim Reed, Yenchieh Cheng, R. Vitti   +14 more
semanticscholar   +1 more source

Inflammatory Complications of Intravitreal Anti-VEGF Injections

Journal of Clinical Medicine, 2021
Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents is a commonly used therapy for numerous retinal diseases. The most commonly used of these medications are bevacizumab, ranibizumab, aflibercept, and brolucizumab ...
J. T. Cox, D. Eliott, L. Sobrin
semanticscholar   +1 more source

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders

EMBO Molecular Medicine, 2021
Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality. Therapeutically impactful targeting of photoreceptors still relies on subretinal vector delivery, which detaches the ...
M. Pavlou, C. Schön, L. Occelli, Axel Rossi, N. Meumann, Ryan F. Boyd, J. Bartoe, J. Siedlecki, M. Gerhardt, Sabrina Babutzka, Jacqueline Bogedein, J. Wagner, S. Priglinger, M. Biel, S. Petersen-Jones, H. Büning, S. Michalakis   +16 more
semanticscholar   +1 more source

Intravitreal Pharmacotherapies for Diabetic Macular Edema: A Report by the American Academy of Ophthalmology.

Ophthalmology (Rochester, Minn.), 2021
PURPOSE To review the evidence on the safety and efficacy of current anti-vascular endothelial growth factor (VEGF) and intravitreal corticosteroid pharmacotherapies for the treatment of diabetic macular edema (DME).
Justis P. Ehlers, S. Yeh, M. Maguire, Justine R. Smith, P. Mruthyunjaya, Nieraj Jain, L. Kim, Christina Y. Weng, C. Flaxel, S. Schoenberger, Stephen J. Kim   +10 more
semanticscholar   +1 more source

Intravitreal hydrogels for sustained release of therapeutic proteins.

Journal of Controlled Release, 2020
This review highlights how hydrogel formulations can improve intravitreal protein delivery to the posterior segment of the eye in order to increase therapeutic outcome and patient compliance.
Blessing C. Ilochonwu, A. Urtti, W. Hennink, T. Vermonden   +3 more
semanticscholar   +1 more source

Comparison of Intravitreal Bevacizumab versus Triamcinolone for the Treatment of Diffuse Diabetic Macular Edema [PDF]

, 2010
Background: Our purpose was to compare the effect of triamcinolone and bevacizumab (Avastin) on the retinal thickness and functional outcome in patients with diabetic macular edema. Methods and Materials: A collective of 32 patients, who had been treated
Haritoglou, Christos, Ulbig, Michael W., Kook, Daniel, Wolf, Armin, Neubauer, Aljoscha Steffen, Kreutzer, Thomas C., Al Saeidi, Rashid   +6 more
core   +1 more source

Experience of intravitreal injections in a tertiary Hospital in Oman

Oman Journal of Ophthalmology, 2015
Aim: To find out statistical data regarding intravitreal injections in an outpatient department setup at a tertiary center in Oman. Design: Retrospective chart review.
Ahmed S Al-Hinai
doaj   +1 more source