Results 101 to 110 of about 1,101,246 (250)

The diagnostic utility of miRNA21 in systemic sclerosis

Reumatismo
Objective. Systemic sclerosis (SSc) is a multisystem autoimmune disease of heterogeneous pathogenesis, including vascular, immunologic, genetic, epigenetic, and environmental factors. Progressive fibrosis is the hallmark of SSc.
Gehad Gamal Maghraby, May Mohsen Tolba Fawzi, Laila Ahmed Rashed, Mohamed Tharwat Hegazy   +3 more
doaj   +1 more source

Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation

Nature Communications, 2017
The peripheral membrane proto-oncogene Src family protein tyrosine kinases (SFKs) transmit growth factor signals to the cytoplasm. Here the authors show that the solubilising factor UNC119 sequesters myristoylated SFKs to maintain its enrichment at the ...
Antonios D. Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, Malte Schmick, Philippe I. H. Bastiaens   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Autoantibody Profile in Systemic Sclerosis

Acta Medica Iranica, 2010
Systemic sclerosis is a generalized disorder of connective tissue clinically characterized by thickening and fibrosis of the skin and by distinctive forms of involvement of internal organs.
Fatemeh Behmanesh, Reza Amin, Mohammad Khajedaluee, Marvin J Fritzler   +3 more
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Systemic Haiku

Murmurations, 2017
Various Systemic Practitioners
doaj   +1 more source

A Comprehensive Review of Treatment Outcomes in Lichen Planus Pigmentosus

Clinical Dermatology Review
Lichen Planus Pigmentosus (LPP) has been a topic of debate and extensive research both with respect to its existence and its treatment. Many treatment options have evolved from topical to systemic each one emerging as an effective treatment in one or the
Rashmi Singh, Rajnish Kumar, Tulika Rai
doaj   +1 more source

Modeling Information Systems as Systems of Systems.

, 2018
Large industrial information systems are composed of dozens of inter-operating software applications. Each of them implements a relatively independent set of functions but also participates to business processes involving more applications. Applications may be COTS acquired from different vendors or custom-developed.
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

LP-012 Patients with systemic lupus erythematosus and hyperproduction of antibodies to anti-U1RNP

Lupus Science and Medicine, 2023
Oxana Desinova, Olga Koneva, Rushana Shayakhmetova, Lidia Ananyeva, Liudmila Garzanova, Olga Ovsyannikova, Mayya Starovoytova   +6 more
doaj   +1 more source