Results 31 to 40 of about 1,101,246 (250)
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani +7 more
wiley +1 more source
Information Systems: Towards a System of Information Systems [PDF]
Information Systems are viewed as a set of services creating a workflow of information directed to specific groups and members. This allows individuals to share ideas and their talents with other members. In such manner, tasks can be carried out both efficiently and effectively.
Majd Saleh, Marie-Hélène Abel
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ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben +4 more
wiley +1 more source
Mingyang Du,1,* Lili Xu,1,* Xiaohao Zhang,2 Xianjun Huang,3 Hui Cao,1 Feng Qiu,1 Wenya Lan,1 Haibo Jiang1 1Cerebrovascular Disease Center, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province, 210029, People ...
Du M +7 more
doaj
SysML contracts for systems of systems [PDF]
This paper proposes and demonstrates an archi- tectural pattern for the contractual specification of interfaces between constituent systems within a System of Systems (SoS). We take a structured approach to the development of the pattern, which we call the Contract Pattern.
Jeremy W. Bryans +4 more
openaire +1 more source
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess +5 more
wiley +1 more source
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak +9 more
wiley +1 more source
Systems engineering to systems biology
Mol Syst Biol. 4: 185 The ‘bottom‐up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top‐down’ fashion, using a variety of network reverse engineering methods, data‐driven modeling and
Yıldırım, Muhammed A, Vidal, Marc
openaire +5 more sources

