FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Improving city transport with the objective to reduce CO2 emissions [PDF]
Transport Problems, 2010 In the past few years traffic volume is increasing. As a consequence, negative external traffic effects are increasing too, in particular CO2 emissions, which result in global warming and climate changes.
Marjan STERNAD, Matjaž KNEZ, Bojan ROSI
doaj
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
A systemic approach to the psychology of racial bias within individuals and society. [PDF]
Nat Rev Psychol, 2023 Skinner-Dorkenoo AL +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Creating Low-carbon Communities: Evaluating the Role of Individual Agency and Systemic Inequality in San Jose, CA [PDF]
, 2019 Following a scholarly need to test compelling community level sociodemographic representations of environmental behaviors and outcomes, a sequential mixed method approach was used to evaluate the connections of human agency and systemic inequalities with
Ronald, Erin Jessica
core +2 more sources
Archives of Pathology & Laboratory Medicine, 1999 Abstract Health care as an industry is going through an evolution similar to that experienced by manufacturing and other service sectors of the world economy. When competition threatens, the traditional management approach is slash-and-burn to manage costs. This approach affects people, services, and facilities.
openaire +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Kailo: a systemic approach to addressing the social determinants of young people's mental health and wellbeing at the local level. [PDF]
Wellcome Open Res, 2023 Hobbs T +29 more
europepmc +1 more source
An analysis of the systemic risks posed by Fannie Mae and Freddie Mac and an evaluation of the policy options for reducing those risks [PDF]
Fannie Mae and Freddie Mac are government-sponsored enterprises that are central players in U.S. secondary mortgage markets. Over the past decade, these institutions have amassed enormous mortgage- and non-mortgage-oriented investment portfolios that ...
Larry D. Wall +2 more
core