Results 41 to 50 of about 129,491 (262)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Appraising cascading systemic risks, ‘watchpoints’, and interventions –methodological reflections

Global Sustainability
Non-technical summary Continued global environmental degradation generates risks to human health, for example, through air pollution, disease, and food insecurity.
Tom H. Oliver, Bob Doherty, Andre Z. Dornelles, Matthew Greenwell, Laura Harrison, Ian Jones, Alistair Lewis, Sarah Moller, Philip Tovey, Nigel Gilbert   +9 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Environmental Benefits of Digital Integration in the Built Environment: A Systematic Literature Review of Building Information Modelling–Life Cycle Assessment Practices

Buildings
Cities are significant contributors to climate change, environmental degradation, and resource depletion. To address these challenges, sustainable strategies in building design, construction, and management are essential, and digitalisation through the ...
Jacopo Tosi, Sara Marzio, Francesca Poggi, Dafni Avgoustaki, Laura Esteves, Miguel Amado   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing the Impact of Crises on the Regulation of the Operation of the Logistics Services Market [PDF]

Problemi Ekonomiki
The modern world is characterized by a high speed of change and instability, which often leads to the emergence of crisis situations. The logistics sector, as one of the key components of economies, is particularly sensitive to such shocks.
Samoilenko Bohdan V.
doaj   +1 more source

Evaluation and Construction of Regional Ecological Network Based on Multi-Objective Optimization: A Perspective of Mountains–Rivers–Forests–Farmlands–Lakes–Grasslands Life Community Concept in China

Applied Sciences, 2022
Landscape degradation and habitat fragmentation are some of the most urgent environmental problems associated with human development and regional integrated planning.
Huabin Xiao, Yanxin Guo, Yue Wang, Yutong Xu, Daliang Liu   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Extending the handprint approach for the assessment of circular solutions to study the potential positive climate impacts of workplace-as-a-service system

Cleaner Engineering and Technology
Circular economy is identified as a fundamental socio-technological systemic solution to solve the over-arching sustainability challenges resulting from human action, which entails an urgent need to implement circular economy solutions.
Mikko Ropo, Kaisa Grönman, Laura Lakanen, Katri Behm, Risto Soukka   +4 more
doaj   +1 more source