Results 131 to 140 of about 1,851,747 (310)

Systemic Failure in the Provision of Safe Food [PDF]

open access: yes
Many deficiencies in the capacity of a food system to deliver safe products are systemic in nature. We suggest a taxonomy of four general ways in which a systemic failure might occur. One relates to the connectedness, or topology, of the system.
Hennessy, David A.   +2 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Codifying systemic design: A toolkit [PDF]

open access: yes, 2016
In this paper we want to reflect on the use of toolkits as a codification strategy to fuel an expanding practice of ‘systemic design’. This critical reflection is rooted in the real‐life experience of bringing together two different sets of skills in ...
Bertels, Peter   +3 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Research collaboration between China and Denmark for development of systemic approaches to agro-ecological pest management without pesticides with focus on vegetable, fruit and berry crops. Proceedings and recommendations from two network workshops [PDF]

open access: yes, 2013
This report is the result of a network project which was established to discuss the potential for collaboration on development of systemic approaches to pest management without pesticides between Chinese and Danish researchers.
Andreasen, Lise   +16 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Assessing tourism capital using two-tiered empirical model

open access: yesAnnals of Tourism Research Empirical Insights
The study aims to develop a novel approach to assess Tourism Capital in resort areas, specifically Zermatt-Matterhorn, between 2014 and 2021. This approach integrates a two-tiered empirical model, where the first tier involves CNN-based image analysis ...
Wadie Othmani, Rym Ammar
doaj   +1 more source

Development of an Environmental Management System for Organic Farms and its Introduction into Practice [PDF]

open access: yes, 2005
Increasing demands for documentation of farm activities as well as environment and quality assurance call for environment adapted management systems, also in organic farming. The model software REPRO is a tool for farm management and consultation.
Huelsbergen, Kurt-Juergen   +1 more
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

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