Systemic Failure in the Provision of Safe Food [PDF]
Many deficiencies in the capacity of a food system to deliver safe products are systemic in nature. We suggest a taxonomy of four general ways in which a systemic failure might occur. One relates to the connectedness, or topology, of the system.
Hennessy, David A. +2 more
core
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Codifying systemic design: A toolkit [PDF]
In this paper we want to reflect on the use of toolkits as a codification strategy to fuel an expanding practice of ‘systemic design’. This critical reflection is rooted in the real‐life experience of bringing together two different sets of skills in ...
Bertels, Peter +3 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Research collaboration between China and Denmark for development of systemic approaches to agro-ecological pest management without pesticides with focus on vegetable, fruit and berry crops. Proceedings and recommendations from two network workshops [PDF]
This report is the result of a network project which was established to discuss the potential for collaboration on development of systemic approaches to pest management without pesticides between Chinese and Danish researchers.
Andreasen, Lise +16 more
core
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Assessing tourism capital using two-tiered empirical model
The study aims to develop a novel approach to assess Tourism Capital in resort areas, specifically Zermatt-Matterhorn, between 2014 and 2021. This approach integrates a two-tiered empirical model, where the first tier involves CNN-based image analysis ...
Wadie Othmani, Rym Ammar
doaj +1 more source
Systemic Design and Evaluation of Ticagrelor-Loaded Nanostructured Lipid Carriers for Enhancing Bioavailability and Antiplatelet Activity. [PDF]
Son GH +8 more
europepmc +1 more source
Development of an Environmental Management System for Organic Farms and its Introduction into Practice [PDF]
Increasing demands for documentation of farm activities as well as environment and quality assurance call for environment adapted management systems, also in organic farming. The model software REPRO is a tool for farm management and consultation.
Huelsbergen, Kurt-Juergen +1 more
core
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source

