Results 121 to 130 of about 1,851,747 (310)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rethinking the concept of Order from a Systemic and Expanded vision of Architecture
Veredes, Arquitectura y Divulgación, 2020 This article seeks to establish a theoretical framework to reinterpret the concept of order from a systemic and expanded vision of architecture.
Jon Arteta Grisaleña
doaj
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
DIIDIn an era characterized by unprecedented volatility, complexity, and systemic disruption, traditional models of organizational change based on linear planning and reactive adaptation have become insufficient.
Valentina De Matteo, Flaviano Celaschi
doaj +1 more source
The financial stress index: identification of systemic risk conditions [PDF]
This paper develops a financial stress index for the United States, the Cleveland Financial Stress Index (CFSI), which provides a continuous signal of financial stress and broad coverage of the areas that could indicate it.
Dieter Gramlich +4 more
core
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
The Terrifying Mystery of the Cave
DIIDThe exploration of systems that Georgina Voss proposes engages with their affective dimensions and the complex interplay between visibility, power, and the unknown, reimagined as The Terrifying Mystery of the Cave.
Georgina Voss, Betti Marenko
doaj +1 more source
The civil servant systemic designer: An emerging context for systemic design practice [PDF]
, 2013 Introduction. Government decisions manifest within the landscape and can greatly affect change within their jurisdiction and beyond. A perfect example would be decisions about regional energy policy.
Veale, Jonathan
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source