Results 101 to 110 of about 1,851,747 (310)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Relating Systems Thinking and Design III
FORMakademisk, 2017 This special issue of Form Akademisk captures some of the systemic design thinking and research presented at the RSD3 conference, held in Oslo, Norway in 2014, and the RSD4 conference, held in Banff, Canada in 2015.
Jodi Forlizzi +2 more
doaj +1 more source
Design research methods in systematic design [PDF]
, 2014 Systemic design is distinguished from user-oriented and service design practices in several key respects: The expansion and negotiation of system boundaries to frame the design situation, the intentional embrace of sociotechnical complexity, and ...
Jones, Peter
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Perspectives on Regulating Systemic Risk [PDF]
, 2016 This book chapter, which synthesizes several of the author’s articles, attempts to provide useful perspectives on regulating systemic risk. First, it argues that systemic shocks are inevitable.
Schwarcz, Steven L.
core +3 more sources
System architecture design [PDF]
Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 2016 Eckert, Claudia, Jankovic, Marija
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
FORMakademisk, 2017 The resent movement of Systemic Design seeks for new synergies between Design and Systems. While the usefulness of systems approaches in design has been fairly obvious, this paper argues that many core concepts in design are beneficial in systems ...
Birger Sevaldson
doaj +1 more source
Facilitating stroke care planning through simulation modelling.
, 2010 Stroke is a leading cause of death and long-term severe disability. A major difficulty facing stroke care provision in the UK is the lack of service integration between the many authorities, professionals and stakeholders involved in the process.
Barlow, James +4 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source