Results 81 to 90 of about 1,851,747 (310)
021 PP: Dual theoretical synergy framework: Developing and refining a method for stakeholder engagement in intervention development [PDF]
, 2017 Stakeholder engagement and patient and public involvement (PPI) is now a key expectation within healthcare policy and in securing research funding and often needs to be evident throughout the research process.
Flowers, P., McDaid, L.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
LandThis study explores the integration of gamification into social and environmental systems to enhance urban biodiversity and foster the co-creation of ecosystems.
Marie Davidová +2 more
doaj +1 more source
Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons [PDF]
, 2016 Zolpidem, a GABAA receptor-positive modulator, is the gold-standard drug for treating insomnia. Zolpidem prolongs IPSCs to decrease sleep latency and increase sleep time, effects that depend on α2 and/or α3 subunit-containing receptors.
Brickley, SG +9 more
core +4 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Systemic Government and the Civil Servant. A New Pattern for Systemic Design
FORMakademisk, 2014 This article examines the emerging application of systemic design methodology within government as practiced by the Alberta Public Service in Edmonton, Canada. A case study, from a practitioner’s perspective, for systemic policy design is presented as an
Jonathan A Veale
doaj +1 more source
Measuring constructive alignment: an alignment metric to guide good practice [PDF]
, 2005 We present a computational model that represents and computes the level to which an educational design is constructively aligned. The model is able to provide ‘alignment metrics’ for both holistic and individual aspects of a programme or module design. A
Tepper, J
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Relating Systems Thinking and Design II. Theoretical Evolution in Systemic Design
FORMakademisk, 2014 We have joined two issues of FORMakademisk to accommodate two sets of articles developed from remarkable early work presented at the 2013 Relating Systems Thinking to Design Symposium in Oslo.
Peter Jones
doaj +1 more source
Design of an ecosystem to foster systemic eco-innovation
FORMakademisk, 2020 The current global environmental situation, with its interconnected problems, requires holistic approaches to provide a cultural paradigm shift and a different economy to overcome the linear one.
Chiara Battistoni, Silvia Barbero
doaj +1 more source