Results 91 to 100 of about 1,851,747 (310)

Countering the Norm, (Re)authoring Our Lives: The Promise Counterstorytelling Holds as a Research Methodology With LGBTQ Youth and Beyond [PDF]

, 2018
Counterstorytelling, a methodology that is rooted in critical race theory, is undergirded by principles that are beneficial to understanding the experiences of lesbian, gay, bisexual, transgender, and queer-identified (LGBTQ) young people from an ...
Gregory, James S., Obejero, Rae Caballero, Wagaman, M. Alex   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Banking Concentration: Implications for Systemic Risk and Safety Net Design [PDF]

This paper explores the impact of banking concentration on safety net design –in particular, deposit insurance– and on systemic risk. The paper focuses on a system characterized by high concentration and low total number of banks. Each issue is addressed
Rodrigo Cifuentes
core   +3 more sources

Stone Circular Design and Material Regeneration

DIID
This contribution aims to investigate the strategic role of design within the ecological transition and the circular economy, through an in-depth analysis of the STONE project.
Gabriele Pontillo, Silvana Bruno, Alessio Tanzini, Fabio Fatiguso   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Navigating systemic risks in low-carbon energy transitions in an era of global polycrisis

Global Sustainability
Non-technical summary Accelerating global systemic risks impel as well as threaten low-carbon energy transitions. Polycrises can undermine low-carbon transitions, and the breakdown of low-carbon energy transitions has the potential to intensify ...
Ashwin K. Seshadri, Ajay Gambhir, Ramit Debnath   +2 more
doaj   +1 more source

On environments as systemic exoskeletons: Crosscutting optimizers and antifragility enablers

, 2015
Classic approaches to General Systems Theory often adopt an individual perspective and a limited number of systemic classes. As a result, those classes include a wide number and variety of systems that result equivalent to each other.
De Florio, Vincenzo
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Systemic/Cybernetic Notion of Design [PDF]

Journal of Systemics, Cybernetics and Informatics, 2019
The purpose of writing this article is 1) to describe the notion1 of "design" in order to show that there is almost no thought-based activity that does not, explicitly or implicitly, contains designing activities, including academic and scientific ones ...
Nagib Callaos
doaj