Results 31 to 40 of about 210,663 (248)

Clinical value of the systemic immune-inflammation index in moyamoya disease

Frontiers in Neurology, 2023
BackgroundMoyamoya disease (MMD) is a rare cerebrovascular disorder with unknown etiology. The underlying pathophysiological mechanism of moyamoya disease remains to be elucidated, but recent studies have increasingly highlighted that abnormal immune response may be a potential trigger for MMD.
Erheng Liu, Erheng Liu, Chengyuan Liu, Chengyuan Liu, Lide Jin, Hu Zhou, Xueyi Tan, Xueyi Tan, Guibo Zhang, Guibo Zhang, Weihua Tao, Xiang Gao, Heng Zhao, Chao Luo, Xuehua Li, Shuaifeng Yang   +15 more
openaire   +3 more sources

Systemic Immune-inflammation Index Is Associated with Symptomatic Cerebral Hyperperfusion after Revascularization Surgery in Moyamoya Disease

Neurologia Medico-Chirurgica
Revascularization surgery for moyamoya disease poses risks of complications, requiring appropriate management. Although precise prediction is difficult, the systemic immune-inflammation index is a calculable marker that reflects systemic inflammatory ...
Taiji YAMAMOTO, Haruto UCHINO, Masaki ITO, Taku SUGIYAMA, Miki FUJIMURA   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The systemic-immune-inflammation index predicts the recurrence of atrial fibrillation after cryomaze concomitant with mitral valve surgery

BMC Cardiovascular Disorders, 2022
Background and aims Inflammation plays a key role in the initiation and progression of atrial fibrillation (AF). The systemic inflammation indexes are easily evaluated and predict AF development.
Yu Luo, Jian Zhang, Tao Liu, Zongtao Yin, Yan Jin, Jinsong Han, Zhipeng Guo, Huishan Wang   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Correlation of systemic immune-inflammation Index with surgical necrotizing enterocolitis

Frontiers in Pediatrics, 2022
BackgroundSystemic Immune-Inflammation Index (SII), known as an easy, economical and useful marker, correlates with the severity of inflammatory response. However, the usefulness of SII in necrotizing enterocolitis (NEC) remains unclear. Therefore, we evaluated the correlation of SII at NEC diagnosis and subsequent surgery.MethodsRetrospective review ...
Wei Feng, Jinping Hou, Chenzhu Xiang, Xiaohong Die, Jing Sun, Zhenhua Guo, Wei Liu, Yi Wang   +7 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Systemic immune inflammation index in patients with recurrent aphthous stomatitis

Brazilian Journal of Otorhinolaryngology, 2022
Recurrent Aphthous Stomatitis (RAS) a chronic idiopathic oral mucosal disease. But yet the etiology and pathogenesis of RAS are not exactly known, it is thought that inflammation play an important role in the pathogenesis. The aim of this study is to demonstrate the role of systemic inflammation among the possible etiological factors of RAS and to find
Fatma Atalay, Ayhan Kars, Kubra Topal, Zeynep Yavuz   +3 more
openaire   +5 more sources

Systemic immune-inflammation index and systemic inflammation response index: novel hematological predictors of obstructive sleep apnea

Frontiers in Neurology
BackgroundWhile the association between obstructive sleep apnea (OSA) and chronic inflammation is well-established, the role of novel hematological indices, such as the systemic immune-inflammation index (SII) and systemic inflammation response index ...
Guohua He, Mingzhu Deng, Yangping Tong, Zhen Wan, Wei Xu, Tieqiao Feng, Wengao Zeng, Ling Xiao, Dandan Yang, Kangping Song, Fangyi Li   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source