Results 51 to 60 of about 6,990,613 (274)

Association of Systemic Inflammatory Response Index and Pan-Immune-Inflammation-Value with Long-Term Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction Patients After Primary Percutaneous Coronary Intervention

, 2023
Yehong Liu,1,* Jie Liu,1,* Longqun Liu,2,* Shaoqing Cao,1,3 Tianhui Jin,1 Liang Chen,1,3 Gangyong Wu,1,3 Gangjun Zong1,3 1Department of Cardiology, The 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, Jiangsu, People’s Republic of
Liu Y, Liu J, Liu L, Zong G, Jin T, Chen L, Cao S, Wu G   +7 more
core  

Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis. [PDF]

, 2015
Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment.
Christopher P Denton, Lopez, H, Etomi, O, Korsa Khan, George R Martin, Abraham, DJ, Guerra, SG, Denton, CP, Sandra G Guerra, Xu Shiwen, David J Abraham, Bahja Ahmed Abdi, Richard J Stratton, Kristina EN Clark, Oseme Etomi, Shiwen, X, Henry Lopez, Abdi, BA, Martin, GR, Stratton, RJ, Khan, K, Clark, KE   +21 more
core   +1 more source

Association between systemic immune-inflammatory markers and the risk of moyamoya disease: a case-control study

, 2023
Background: Systemic immune-inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic immune-inflammatory index (SII) are associated with the prognosis of many ...
Junsheng Li (276905), Wei Liu (20030), Yuanren Zhai (13583872), Xun Ye (199116), Xingju Liu (8071667), Dong Zhang (73558), Yan Zhang (8098), Qiheng He (12715928), Rong Wang (59795), Xiaofan Yu (3498107), Peicong Ge (8071664), Chenglong Liu (317596), Qian Zhang (49333)   +12 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome [PDF]

, 2011
While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a ...
Tadokera, Rabecca
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Associations between pretreatment composite inflammatory indices and pathological response to neoadjuvant therapy in breast cancer: a retrospective cohort study

Frontiers in Oncology
BackgroundPretreatment inflammatory indices may reflect the host immune-inflammatory status in breast cancer. Evidence comparing multiple composite indices across pathological response endpoints after neoadjuvant therapy remains limited.
Yuhong Zhang, Cailing Tong
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

PROGNOSTIC ROLE OF INFLAMMATORY INDICES IN RISK CLASSIFICATION OF PATIENTS WITH COVID-19

Sabiad, 2022
Objective: The Covid-19 pandemic has revealed the importance of an evidence-based efficient triage system in the early identification of high risk patients and the rational use of limited medical resources for reducing mortality.
Maide Hacer Alagöz, Ayşe Enise Göker, Evin Ademoğlu   +2 more
doaj   +1 more source