Results 41 to 50 of about 3,045,517 (253)
Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Cellular & Molecular Biology LettersBackground Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood.
Deepika Watts +12 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Systemic modeling of environmental impacts in construction: a systematic review
Results in EngineeringThe construction industry is one of the major contributors to environmental degradation, social disruption, and economic fluctuations. To mitigate these challenges, the environmental, social, and economic aspects need to be analyzed in an
Roya Amrollahibuki, Conrad Boton
doaj +1 more source
PCIC annual report 2021-2022 [PDF]
, 2022 The Pacific Climate Impacts Constortium (PCIC) corporate report for 2021 ...
Pacific Climate Impacts Consortium (PCIC)
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Systemic risk: Opportunities for inter- and transdisciplinary science to improve societal resilience
iScienceSystemic risks will be amplified due to global warming as climate-related shocks, like extreme weather events, cause cascading and compounding impacts across sectors and systems. To better understand and manage systemic risk, inter- and transdisciplinary
Jana Sillmann +3 more
doaj +1 more source
The Impacts of Systemic Immune-Inflammation Index on Clinical Outcomes in Gallbladder Carcinoma
Frontiers in Oncology, 2020 Background: Systemic immune-inflammation index (SII) is considered to be a prognostic marker in several cancers. However, the prognostic value of baseline pre-operative SII in gallbladder carcinoma (GBC) has not been evaluated.
Lejia Sun +13 more
doaj +1 more source