Results 41 to 50 of about 223,207 (264)

The Impact of Pazopanib on the Cardiovascular System [PDF]

Journal of Cardiovascular Pharmacology and Therapeutics, 2018
Pazopanib is an approved treatment for renal cell carcinoma and a second-line treatment for nonadipocytic soft-tissue sarcoma. However, its clinical efficacy is limited by its cardiovascular side effects. Pazopanib and other vascular endothelial growth factor receptor tyrosine kinase inhibitors have been associated with the development of hypertension,
Cody N. Justice, Mohamed H. Derbala, Tesla M. Baich, Amber N. Kempton, Aaron S. Guo, Thai H. Ho, Sakima A. Smith   +6 more
openaire   +2 more sources

The Impact of the Apelinergic System on the Cardiovascular System

International Journal of Molecular Sciences
The apelin–ELABELA–APJ axis, collectively known as the apelinergic system, has emerged as a key regulator of cardiovascular homeostasis. Acting through G-protein-coupled mechanisms, it modulates vascular tone, cardiac contractility, angiogenesis, fluid balance, and metabolism.
Rafał Wyderka, Łukasz Osuch, Bogusława Ołpińska, Maria Łoboz-Rudnicka, Dorota Diakowska, Anna Leśków, Joanna Jaroch   +6 more
openaire   +3 more sources

Planting area and production decreased for winter-triticeae crops but increased for rapeseed in Ukraine with climatic impacts dominating

Geography and Sustainability
On-time mapping dynamics of crop area, yield, and production is important for global food security. Such information, however, is often not available. Here, we used satellite information, a spectral-phenology integration approach for mapping crop area ...
Jichong Han, Yuchuan Luo, Zhao Zhang, Jialu Xu, Yi Chen, Senthold Asseng, Jonas Jägermeyr, Christoph Müller, Jørgen E Olesen, Reimund Rötter, Fulu Tao   +10 more
doaj   +1 more source

The Impact of Nanomaterials in Immune System [PDF]

Immune Network, 2010
As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity. In this article we review the immunological influences induced by several nanomaterials and emphasize ...
Jiyoung Jang, Dae-Hyoun Lim, In-Hong Choi   +2 more
openaire   +3 more sources

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Managing the Systemic Impact of Periodontitis

Medicina, 2022
Periodontitis is a microbially driven host-mediated disease that leads to loss of periodontal attachment and bone. It is associated with elevation of systemic inflammatory markers and with the presence of systemic co-morbidities. Furthermore, periodontal treatment leads to a 24–48 h-long acute local and systemic inflammatory response.
Giuseppe Mainas, Mark Ide, Manfredi Rizzo, Antonio Magan-Fernandez, Francisco Mesa, Luigi Nibali   +5 more
openaire   +5 more sources

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Toward a framework for systemic multi-hazard and multi-risk assessment and management

iScience, 2023
Summary: In our increasingly interconnected world, natural hazards and their impacts spread across geographical, administrative, and sectoral boundaries.
Stefan Hochrainer-Stigler, Robert Trogrlić Šakić, Karina Reiter, Philip J. Ward, Marleen C. de Ruiter, Melanie J. Duncan, Silvia Torresan, Roxana Ciurean, Jaroslav Mysiak, Dana Stuparu, Stefania Gottardo   +10 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Numerical Study of Fluidic Thrust Vector Control Using Dual Throat Nozzle

Journal of Applied Fluid Mechanics, 2021
Compared to a variety of mechanical vectoring nozzles, fluidic vectoring nozzles possess more research value nowadays. The dual throat nozzle is gradually developing into an outstanding technology to handle supersonic and hypersonic aircraft deflections.
K. X. Wu, T. H. Kim, H. D. Kim
doaj