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Systemic inflammation after trauma
Injury, 2007Trauma is still one of the main reasons for death among the population worldwide. Mortality occurring early after injury is due to "first hits", including severe organ injury, hypoxia, hypovolaemia or head trauma. Massive injury leads to activation of the immune system and the early inflammatory immune response after trauma has been defined as systemic
Andreas, Lenz +2 more
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Inflammation and the apopto-phagocytic system
Immunology Letters, 2006Although under normal conditions many cells die daily mainly by apoptosis in human tissues, inflammation does not occur. The redundant function of a relatively large number of molecules are available to recognize changes occurring on the surface of apoptotic cells, to opsonize the dead cells and to engulf the apoptotic cells previously opsonized or not.
Gyöngyike, Májai +2 more
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Role of the Melanocortin System in Inflammation
Annals of the New York Academy of Sciences, 2006Abstract: In recent years, scientific interest in melanocortins (MC) has progressively increased due to their wide range of effects and expression on various tissues.Primarily discovered as mediators of skin pigmentation, recent research has shown their important roles in various body functions, such as energy homeostasis, sexual function, and ...
Christian, Maaser +2 more
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Loss of p53 triggers Wnt-dependent systemic inflammation to drive breast cancer metastasis
Nature, 2019Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and ...
M. Wellenstein +19 more
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Systemic inflammation markers and the prevalence of hypertension: A NHANES cross-sectional study
Hypertension Research, 2023Junpeng Xu +8 more
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Activin A and follistatin in systemic inflammation
Molecular and Cellular Endocrinology, 2004Inflammation is a complex process regulated by a cascade of cytokines and growth factors. This review summarizes the emerging evidence implicating activin A and follistatin in the inflammatory process. Our recent studies have highlighted that activin A is released early in the process as part of the circulatory cytokine cascade during acute systemic ...
Jones, Kristian. L. +3 more
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Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders
Inflammation Research, 2023Shilin Jia, Hui Yang, F. Huang, W. Fan
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Inflammation, Sepsis, and the Coagulation System
HämostaseologieAbstractSepsis has been a major health problem for centuries and it is still the leading cause of hospital deaths. Several studies in the past decades have identified numerous biochemical abnormalities in severe cases, and many of these studies provide evidence of the perturbation of the hemostatic system.
János, Kappelmayer +3 more
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Controlling the complement system in inflammation
Immunopharmacology, 1997Inappropriate or excessive activation of the complement system can lead to harmful, potentially life-threatening consequences due to severe inflammatory tissue destruction. These consequences are clinically manifested in various disorders, including septic shock, multiple organ failure and hyperacute graft rejection.
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