Results 141 to 150 of about 3,434,192 (362)

Systemic inflammation after inspiratory loading in chronic obstructive pulmonary disease

, 2008
Antonia Fuster, Jaume Sauleda, Ernest Sala, Bernardí Barceló1, Jaume Pons2, Miguel Carrera, Aina Noguera1, Bernat Togores, Alvar GN AgustíServeis de Pneumologia, 1Analisis Clinics, and 2Inmunología, Hospital ...
Ernest Sala, Jaume Pons, Antonia Fuster, et al, Bernardí Barceló, Jaume Sauleda   +5 more
core  

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation

, 2020
Copyright © 2020 Barron, Gartlon, Dawson, Atkinson and Pardon. Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs).
Dawson, Lee A, Barron, Matthew R, Pardon, Marie-Christine, Atkinson, Peter J, Gartlon, Jane   +4 more
core   +2 more sources

Myocardial and Systemic Inflammation in Acute Stress-Induced (takotsubo) Cardiomyopathy

Circulation, 2019
Background: Acute stress-induced (takotsubo) cardiomyopathy can result in a heart failure phenotype with a prognosis comparable with that of myocardial infarction.
C. Scally, H. Abbas, T. Ahearn, J. Srinivasan, A. Mezincescu, A. Rudd, N. Spath, A. Yucel-Finn, R. Yuecel, K. Oldroyd, C. Dospinescu, G. Horgan, P. Broadhurst, A. Henning, D. Newby, S. Semple, Heather Wilson, D. Dawson   +17 more
semanticscholar   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Therapeutic effects of physostigmine during systemic inflammation

, 2018
Katharina Effenberger-Neidnicht,1 Johannes Jägers,2 Rabea Verhaegh,1 Michael Kirsch1 1Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, Germany Introduction ...
Effenberger-Neidnicht K, Verhaegh R, Kirsch M, Jägers J   +3 more
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Effect of inflammation on the relationship of pulse pressure and mortality in haemodialysis.

, 2011
The effect of hypertension on mortality in haemodialysis patients is controversial and can be confounded by non-traditional risk factors like systemic inflammation. This study examined the effect of systolic blood pressure (SBP), diastolic blood pressure
Herzog, CA, Collins, AJ, Banerjee, D
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study

, 2010
Includes abstract.Includes bibliographical references (leaves 113-135).Twenty percent of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a ...
Mahne, Anna Cecilia
core  

Intravitreal Adalimumab for the Control of Breakthrough Intraocular Inflammation [PDF]

, 2018
Purpose: Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. Methods: Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring ...
Mehanna, Carl Joe, Al-Ghadban, Sara I., Mansour, Ahmad Mohammed Farid Mahmoud, Abdul Fattah, Maamoun, Kheir, Wajiha J., Hamam, Rola N., El-Sabban, Marwan E.   +6 more
core   +1 more source