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The Complement System and Inflammation
1979The complement system was discovered toward the end of the nineteenth century as a heat-labile principle in fresh nonimmune serum which was essential for the bactericidal activity of serum from immunized guinea pigs. It has subsequently been established as a very important factor of constitutive immunity. The complement system functions as an auxiliary
J O, Minta, H Z, Movat
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Apelin/APJ system in inflammation
International Immunopharmacology, 2022Apelin, an endogenous ligand for the G protein-coupled receptor (APJ), is widely distributed within the central nervous system and diverse organs in human and animals. Recent studies indicate that the apelin/APJ system plays an important role in physiological and pathophysiological situations.
Xu Wang +5 more
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Systems Biology and Inflammation
2010Inflammation is a complex, multiscale biological response to threats - both internal and external - to the body, which is also required for proper healing of injured tissue. In turn, damaged or dysfunctional tissue stimulates further inflammation.
Yoram, Vodovotz, Gary, An
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Central nervous system inflammation
European Journal of Anaesthesiology, 2008Activation of inflammation is the hallmark of pathological processes that follow acute injury. This process is mediated by inflammatory cytokines and adhesion molecules that reside on the surface of endothelium, leucocyte and inflammatory cells. Attenuation of the adhesion cascade has been the subject of several basic science and clinical trials in the
S G, Soriano, S, Piva
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The neutrophil and systemic inflammation
Joint Bone Spine, 2012Joint Bone Spine - In Press.Proof corrected by the author Available online since lundi 6 fevrier ...
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Termination of inflammation in the nervous system
Revue Neurologique, 2007T cell apoptosis has been studied in animal models for human autoimmune disorders of the nervous system and in other tissues devoid of specialized immune-defense mechanisms. Our data suggest that the central nervous system has a high potential to eliminate T cell inflammation, whereas this mechanism is less effective in the peripheral nervous system ...
R, Gold, R A, Linker, A, Chan
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Systemic Response to Inflammation
Nutrition Reviews, 2007The systemic inflammatory response represents a coordinated set of physiologic actions that serve to fight infection, heal wounds, and promote recovery from external stressors. Thus, under most circumstances an intact systemic inflammatory response increases the likelihood of a successful outcome following acute injury or infection.
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Systemic effects of inflammation in bronchiectasis
Respiratory Medicine, 1991A group of bronchiectatic subjects in the clinically stable state were studied for systemic evidence of inflammation. The following parameters were evaluated: body weight, serum albumin, serum globulin, serum alpha 1-antitrypsin (alpha 1 AT) and peripheral white cell count.
Ip, M, Lam, WK, Chan, JC, Liong, E
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Systemic Markers of Inflammation in Periodontitis
Journal of Periodontology, 2005This literature review summarizes current knowledge on the systemic levels of selected markers of inflammation in periodontitis. From samples of peripheral blood the following cellular factors are discussed: total number of white blood cells, red blood cells, and thrombocytes.
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Systemic inflammation and Alzheimer's disease
Biochemical Society Transactions, 2011A number of studies demonstrate disturbances of the central innate immune system in AD (Alzheimer's disease). In animal and human studies, there is evidence of close communication between systemic and central innate immune systems. Animal models of neurodegeneration show evidence of an exaggerated central innate immune response following systemic ...
Clive, Holmes, Joe, Butchart
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