Results 31 to 40 of about 319,415 (208)

Evaluation of the Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index in Ankylosing Spondylitis Patients

İstanbul Medical Journal, 2023
Introduction: The aim of this study was to investigate the relationship between the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with ankylosing spondylitis (AS).
Burak Tayyip Dede, Berat Bulut, Muhammed Oğuz, Fatih Bağcıer, Ebru Aytekin   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Association between systemic Immune-inflammation index, systemic inflammation response index and adult osteoarthritis: national health and nutrition examination survey

BMC Musculoskeletal Disorders
Background Osteoarthritis (OA) is a degenerative and inflammatory joint disease caused by multiple factors, the underlying mechanisms of which are not fully understood. The systemic immune-inflammation index (SII) and systemic inflammation response index
Xiao-Jun Chen, Shu-Fen Liao, Qiu-Yi Ouyang, Ping Wang, Gui-Lan Huang, Shu-Yan Zeng, Qin Guo, Jin-Yan Li, Yang-Xi Shen, Na Li, Liu-Fang Huang, Feng-Qiu Gong   +11 more
doaj   +1 more source

The Role of Systemic Immune-Inflammation Index and Systemic Inflammation Response Index in the Diagnosis of Bell’s Palsy

Journal of Behçet Uz Children's Hospital
Objective: Recent studies showed that Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI) can be used as inflammatory markers.
Betül Öztürk, Raziye Merve Yaradılmış, Muhammed Mustafa Güneylioğlu, Ali Güngör, İlknur Bodur, Aytaç Göktuğ, Orkun Aydın, Meltem Akçaboy, Ergin Atasoy, Can Demir Karacan, Nilden Tuygun   +10 more
doaj   +1 more source

Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke

European Journal of Medical Research, 2022
Background Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel and convenient measurements that ...
Kai-bin Lin, Feng-hua Fan, Ming-qi Cai, Yin Yu, Chuan-liang Fu, Lu-yue Ding, Yu-dong Sun, Jia-wen Sun, Yong-wang Shi, Zhi-feng Dong, Min-Jie Yuan, Shuai Li, Yan-peng Wang, Kan-kai Chen, Ji-ni Zhu, Xin-wei Guo, Xue Zhang, Yu-wu Zhao, Jing-bo Li, Dong Huang   +19 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Relationship between systemic immune inflammation index and systemic inflammation response index values and prognosis in patients with burns

Medicine Science
To determine the relationship between systemic immune inflammation index (SyII) and systemic inflammation response index (SyIRI) values and prognosis in adult and pediatric cases treated for deep partial thick and full thick burns.
Serap Samut Bulbul, Alper Ceylan, Metin Ocak, Selim Gorgum, Tolga Pamuk, Mesut Oterkus   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke

Journal of International Medical Research
Objective Endovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile ...
Zubing Xu, Linghong Guo, Yunqing Chen, Dandan Chen, Hudie Zhang, Xilin Xiong, Yan Gong, Qiulong Yu, Chenying Zeng, Lanjiao Zhang, Qin Huang, Jinchong Zhang, Keji Zou, Pu Fang, Daojun Hong, Jing Lin, Xian Liu, Xiaobing Li   +17 more
doaj   +1 more source