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MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome. [PDF]

open access: yesCell Mol Immunol
Wu X   +23 more
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The systemic inflammatory response syndrome

Microbes and Infection, 2006
The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic ...
Craig M Coopersmith
exaly   +3 more sources

The systemic inflammatory response syndrome

Trauma, 2001
The systemic inflammatory response syndrome (SIRS) describes the clinical presentation of patients with systemic activation of the inflammatory response from any underlying cause. SIRS is a common problem in acute medical and surgical practice and an important cause of morbidity and mortality.
Hanif Meeran, Mark Messent
exaly   +2 more sources

The systemic inflammatory response syndrome

Best Practice & Research Clinical Anaesthesiology, 2004
Sepsis and septic shock are the leading causes of death in intensive care units in developed countries despite recent advances in critical care medicine. Sepsis is the systemic inflammatory response to infection frequently associated with hypoperfusion followed by tissue injury and organ failure. The activation of monocytes/macrophages and neutrophils,
Markus A, Weigand   +3 more
openaire   +3 more sources

Systemic Inflammatory Response Syndrome

Neonatal Network, 2001
Despite advances in perinatal care in the past decade, sepsis and its complications continue to present problems for the neonate, remaining a major cause of neonatal morbidity and mortality. Sepsis research is focusing on how the neonate (host) responds to bacteria.
Ira Adams-Chapman, Barbara J. Stoll
openaire   +3 more sources

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