Results 91 to 100 of about 304,324 (330)
USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
Advanced Science, EarlyView.This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang +9 more
wiley +1 more source
A case of Lemierre syndrome combined with a suspected systemic lupus erythematosus flare
SAGE Open Medical Case Reports, 2019 Lemierre syndrome develops in healthy young patients as a result of bacteremia after oral cavity infection. It causes thrombophlebitis in the internal jugular vein.
Teruhiro Fujii +4 more
doaj +1 more source
Journal of Medical Case Reports, 2012 Introduction The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease. Case presentation We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus ...
Maamar Mouna +5 more
doaj +1 more source
Inhibition of Leukocyte Agglutination by Serum from Patients with Systemic Lupus Erythematosus: A Manifestation of the L.E. Cell Phenomenon [PDF]
, 1958 STANLEY L. LEE, Florence Schultz
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Clinics, 2012 OBJECTIVE: To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity,
Mariana Postal +5 more
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Lesions of Joints and Tendon Sheaths in Systemic Lupus Erythematosus [PDF]
, 1959 B. Cruickshank
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Disease course patterns in systemic lupus erythematosus
Lupus, 2018 Background Disease activity in systemic lupus erythematosus follows three different courses: long quiescent, relapsing remitting and persistently active. However, the patterns of disease course since diagnosis are not known.
K. Tselios +5 more
semanticscholar +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey +6 more
wiley +1 more source
Journal of Translational Autoimmunity, 2020 Neuropsychiatric systemic lupus erythematosus is an autoimmune disorder characterized by an irregular exchange between the central nervous system and the immune system, leading to the outbreak of neurological conditions with possible disabling effects ...
Sangita Khatri +7 more
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