Results 101 to 110 of about 872,427 (309)

Pharmacokinetics, Safety, and Tolerability of Single‐Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double‐Blind, Phase 1 Studies

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dazukibart is a humanized monoclonal antibody selectively targeting interferon‐β. The pharmacokinetics (PK), safety, tolerability, and immunogenicity of dazukibart were evaluated in 2 double‐blind, randomized, placebo‐controlled, single‐dose, Phase 1 studies in healthy adults in China (Study 1: N = 18; dazukibart 900 mg = 15; placebo = 3) and ...
Naihan Chen, Yamato Sano, Xiaohong Wang, Shuiyi Hu, Junichi Tabira, Xin Luo, Hiroki Yoshimatsu, John Prybylski, Myron Chu, Haiyan Li, Kenji Takazawa   +10 more
wiley   +1 more source

LP-199 Medications given to patients with incomplete systemic lupus erythematosus

Lupus Science and Medicine, 2023
Anastasiia Shumilova, Yulia Gorbunova, Tatiana Popkova, Tatiana Panafidina, Liubov Kondrateva, Alexandr Lila   +5 more
doaj   +1 more source

Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus

Clinics, 2012
OBJECTIVE: To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity,
Mariana Postal, Nailu Angélica Sinicato, Karina Oliveira Peliçari, Roberto Marini, Lilian Tereza Lavras Costallat, Simone Appenzeller   +5 more
doaj  

Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto’s thyroiditis and pernicious anemia: a case report

Journal of Medical Case Reports
Background Evans syndrome is a rare disorder characterized by the simultaneous or sequential combination of autoimmune hemolytic anemia and immunological thrombocytopenia, together with a positive direct antiglobulin test.
Maryam Mansour, Arwa Shamasnah, Deema Alsaadi, Saja Abu Saif, Akram krama   +4 more
doaj   +1 more source

The Role of Acth and Cortisone in the Treatment of Systemic Lupus Erythematosus [PDF]

, 1956
J. N. Harris‐Jones
openalex   +1 more source

Confirmation of Fixed Quarterly Riliprubart Regimen in Patients with Cold Agglutinin Disease Using Population PK/PD and Exposure‐Response Analyses

Clinical Pharmacology &Therapeutics, EarlyView.
Riliprubart is a second‐generation, humanized immunoglobulin G4 that inhibits only the activated form of the C1s component of the proximal classical complement pathway. The clinical studies of riliprubart conducted thus far for the treatment of cold agglutinin disease (CAD), a rare autoimmune disease, include a Phase 1 first‐in‐human study in healthy ...
Timothy Chow, Marek Wardecki, Michael Storek, Nancy Wong   +3 more
wiley   +1 more source

LP-203 The new markers of systemic lupus erythematosus activity: focus on interleukin (IL)-1b and soluble IL-2 receptor

Lupus Science and Medicine, 2023
Mariia Aristova, Tatyana Panafidina, Yulia Gorbunova, Anastasiya Avdeeva, Tatyana Popkova   +4 more
doaj   +1 more source

Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus. [PDF]

, 1965
F Paronetto, David Koffler
openalex   +1 more source

Deep Reinforcement Learning for Personalized Diagnostic Decision Pathways Using Electronic Health Records: A Comparative Study on Anemia and Systemic Lupus Erythematosus [PDF]

arXiv
Background: Clinical diagnosis is typically reached by following a series of steps recommended by guidelines authored by colleges of experts. Accordingly, guidelines play a crucial role in rationalizing clinical decisions but suffer from limitations as they are built to cover the majority of the population and fail at covering patients with uncommon ...
arxiv  

Classification on Large Networks: A Quantitative Bound via Motifs and Graphons [PDF]

arXiv, 2017
When each data point is a large graph, graph statistics such as densities of certain subgraphs (motifs) can be used as feature vectors for machine learning. While intuitive, motif counts are expensive to compute and difficult to work with theoretically. Via graphon theory, we give an explicit quantitative bound for the ability of motif homomorphisms to
arxiv