Results 101 to 110 of about 323,501 (341)

Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System [PDF]

open access: yes, 2019
Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis.
Agarwal   +268 more
core   +1 more source

Single‐Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion

open access: yesAdvanced Science, EarlyView.
Single‐cell transcriptomics and clinical data show that during myasthenia gravis (MG) exacerbation, bone marrow mature neutrophils expand and enter blood, with parallel increase of B‐cell activating factor (BAFF)–positive neutrophils. Experimental autoimmune myasthenia gravis (EAMG) confirms a pathogenic interferon‐γ (IFN‐γ)–neutrophil–BAFF axis ...
Zhaoxu Zhang   +5 more
wiley   +1 more source

The use of sex hormones in women with rheumatological diseases [PDF]

open access: yes, 2011
A number of rheumatological diseases predominantly affect women of reproductive age. There has always been concern that the use of oestrogen-containing agents such as combined hormonal contraception and hormone therapy might aggravate these conditions ...
Gebbie, AE   +5 more
core  

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

open access: yesAdvanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen   +15 more
wiley   +1 more source

Recurrent podocytopathy in a patient with systemic lupus erythematosus

open access: yesSAGE Open Medical Case Reports, 2017
Podocytopathy in systemic lupus erythematosus is characterised by diffuse foot process effacement without significant peripheral capillary wall immune deposits as seen on electron microscopy.
Shereen Paramalingam   +3 more
doaj   +1 more source

Systemic lupus erythematosus associated with sickle-cell disease: a case report and literature review

open access: yesJournal of Medical Case Reports, 2012
Introduction The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease. Case presentation We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus ...
Maamar Mouna   +5 more
doaj   +1 more source

Influence of 1 Alpha, 25-Dihydroxyvitamin D3 on T helper 17 cells and related cytokines in systemic lupus erythematosus [PDF]

open access: yes, 2015
Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity.
Abdollahi, N.   +7 more
core  

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

open access: yesAdvanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian   +7 more
wiley   +1 more source

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