Results 261 to 270 of about 872,427 (309)

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Systemic Lupus Erythematosus Features in Elderly Patients: Case-Based Review. [PDF]

J Clin Med
Ceasovschih A, Alexa RE, Șorodoc V, Asaftei A, Stoian DC, Morărașu BC, Balta A, Lionte C, Stoica A, Sîrbu O, Constantin M, Diaconu AD, Lăcătușu CM, Grigorescu ED, Șorodoc L.   +14 more
europepmc   +1 more source

Anti‐Ro52/TRIM21 autoantibodies predict Sjögren's syndrome in patients with primary biliary cholangitis

Hepatology Research, EarlyView.
Abstract Background and aims Sjögren's syndrome is a common comorbidity in patients with primary biliary cholangitis (PBC). Anti‐Ro52 autoantibodies against the protein TRIM21 are often seen in Sjögren's syndrome. TRIM21 consists of four domains (PRY/SPRY, Coiled‐Coil, B‐box, and RING domain), each with a specific function.
Marie Louise Næstholt Dahl, Trine‐Line Korsholm, Jakob Hauge Mikkelsen, Malene Hvid, Ayad Babaee, Matias Hauge Böttcher, Jesper Bach Hansen, Peter Holland‐Fischer, Christian Brix Folsted Andersen, Henning Grønbæk, Bent Deleuran   +10 more
wiley   +1 more source

Serum lipid profile in systemic lupus erythematosus. [PDF]

Front Immunol
Xuan J, Deng C, Lu H, He Y, Zhang J, Zeng X, Sun Y, Chen S, Liu Y.   +8 more
europepmc   +1 more source

Connective tissue disease‐associated interstitial lung disease: an approach to treatment amidst an expanding evidence base

Internal Medicine Journal, EarlyView.
ABSTRACT Connective tissue disease‐associated interstitial lung disease (CTD‐ILD) comprises a heterogenous group of conditions characterised by immune‐mediated fibro‐inflammatory pulmonary injury. Although the disease course is variable, CTD‐ILD can progress to respiratory failure and thus has a profound impact on morbidity and mortality.
Michael Hong, Elizabeth Veitch, Sandhya Limaye   +2 more
wiley   +1 more source

Systemic Lupus Erythematosus Presenting With Autoimmune Myelofibrosis in a Young Woman: A Case Report. [PDF]

Clin Case Rep
Nodeh MM, Rezaieyazdi Z, Karimoddini M, Jafarian AH, Ghamari M.   +4 more
europepmc   +1 more source

Not just skin deep: reframing chronic inflammatory skin disease as a systemic threat

Internal Medicine Journal, EarlyView.
Abstract Chronic inflammatory skin disease is more than skin deep, with several cutaneous disease entities associated with an increased risk of cardiovascular disease. Notably, psoriasis carries a markedly increased risk of cardiovascular disease, along with a significant comorbid burden.
Annika Smith, Clara K. Chow
wiley   +1 more source

Uncovering Genetic Variation in Systemic Lupus Erythematosus Risk Variants in Indigenous Peruvians. [PDF]

ACR Open Rheumatol
Lanata CM, Oppong RF, Horton MK, Borda V, Ugarte-Gil MF, Nititham J, Tarazona-Santos E, O'Connor TD, Guio H, Criswell LA.   +9 more
europepmc   +1 more source

Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis

Immunology, EarlyView.
Human CD4 follicular helper T cells (TFH) are a heterogeneous cell population at the phenotypic, localisation and in situ functional level. The application of complementary methods is a prerequisite for a comprehensive delineation of the immune landscape at the tissue level. ABSTRACT Given the role of follicular immune dynamics, especially the germinal
Spiros Georgakis, Michail Orfanakis, Craig Fenwick, Cloe Brenna, Simon Burgermeister, Helen Lindsay, Giuliana Xavier de Medeiros, Fernanda Romano Bruno, Susan Pereira Ribeiro, Raphael Gottardo, Giuseppe Pantaleo, Constantinos Petrovas   +11 more
wiley   +1 more source

Langerhans cells infiltration in lymph nodes of patients with systemic lupus erythematosus. [PDF]

Lupus Sci Med
Qian J, Li L, Lv J, Jiang Y, Ma Q, Pan H, Wei X, Yang Z, Yu S, Fan Y, Teng J, Yang C, Zhang A, Yang Y, Shi H.   +14 more
europepmc   +1 more source