Results 191 to 200 of about 67,974,619 (226)

Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2014
This study tested the concurrent validity of the systemic lupus erythematosus responder index (SRI) in assessing improvement in juvenile-onset systemic lupus erythematosus (jSLE).The SRI considers changes in the SELENA-SLEDAI, BILAG and a 3-cm visual analogue scale of physician-rated disease activity (PGA) to determine patient improvement.
Mina R, Klein Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, Onel K, Tucker L, O'Neil KM, Punaro M, Levy DM, Haines K, MARTINI, ALBERTO, Ruperto N, Lovell D, Brunner HI   +15 more
openaire   +4 more sources

Juvenile-Onset Systemic Lupus Erythematosus (jSLE) – Pathophysiological Concepts and Treatment Options

Best Practice and Research in Clinical Rheumatology, 2017
The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE) manifests before the age of 16 years in 10-20% of all cases. Clinical courses are more severe, and organ complications are more common in patients with juvenile SLE. Varying gender distribution in different age groups and increasing severity with younger age and the ...
Christian M Hedrich, Michael W Beresford, Eve M.D. Smith   +2 more
exaly   +3 more sources

Pulmonary hypertension in juvenile-onset systemic lupus erythematosus: a case series

Clinical and Experimental Rheumatology, 2022
Systemic lupus erythematosus (SLE) is a rare multisystem autoimmune disorder with a variable clinical phenotype. Pulmonary hypertension (PHTN) is a recognised (and not uncommonly asymptomatic) complication of the condition with an associated poor prognosis in adults.
Platt, Caroline, Longthorpe, Catherine, Sit, Jacqueline, Marks, Stephen D, Harmer, Matthew, Ciurtin, Coziana, Ramanan, Athimalaipet V, Beresford, Michael W   +7 more
openaire   +3 more sources

Anti‐C1q Antibodies in Juvenile‐Onset Systemic Lupus Erythematosus

Annals of the New York Academy of Sciences, 2009
The objective of this study was to evaluate the presence of anti‐C1q antibodies Hospital Israelita Albert Einstein Research Institute, São Paulo, Brazil in 67 juvenile systemic lupus erythematosus (JSLE) patients and 26 healthy controls and to assess the association of these antibodies with disease activity, nephritis, and presence of anti‐double ...
A A, Jesus, C A, Silva, M, Carneiro-Sampaio, M, Sheinberg, C L, Mangueira, S K, Marie, B L, Liphaus   +6 more
openaire   +2 more sources

Ocular Manifestations in Children with Juvenile-Onset Systemic Lupus Erythematosus

Seminars in Ophthalmology, 2017
To study the ocular manifestations of juvenile systemic lupus erythematosus (JSLE), including the ocular side-effects of the systemic medications used.A descriptive cross-sectional study on 40 children diagnosed with JSLE was conducted. Ophthalmological and laboratory investigations as well as a calculation of the Systemic Lupus Disease Activity Index ...
Ghada, Gawdat, Dina, El-Fayoumi, Huda, Marzouk, Yomna, Farag   +3 more
openaire   +2 more sources

THU0330 Damage in juvenile-onset systemic lupus erythematosus

Annals of the Rheumatic Diseases, 2012
Background Children and adolescents with juvenile-onset systemic lupus erythematosus (jSLE) face considerable morbidity due to sequelae of disease activity, comorbidities and adverse effects of treatment. In order to improve the management of these patients, it is essential to better understand the risk factors associated with the development of ...
P. Costa Reis, J. Isgro, S. Nativ, C. Yildirim-Toruner, A. Starr, L. Imundo, A. Eichenfield   +6 more
openaire   +1 more source

Analysis of serum IL-38 in juvenile-onset systemic lupus erythematosus

Modern Rheumatology, 2018
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with widespread immunologic abnormalities and multiple organ involvement [1].
Yusuke, Takeuchi, Tomoko, Seki, Norimoto, Kobayashi, Kenji, Sano, Tomonari, Shigemura, Hisashi, Shimojo, Kazuhiko, Matsumoto, Kazunaga, Agematsu   +7 more
openaire   +2 more sources

Multi-disciplinary care in juvenile-onset systemic lupus erythematosus

British Journal of School Nursing, 2012
Juvenile onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease that can affect any part of the body including skin, joints and organs and can be associated with significant morbidity and mortality. Multi-disciplinary care of children and young people with JSLE is essential, in close partnership with schools.
Jane Kelly, Jane Dunnage, Michael W Beresford, Liza J McCann   +3 more
openaire   +1 more source

Juvenile-onset systemic lupus erythematosus: how to diagnose and manage

Paediatrics and Child Health, 2015
Abstract Systemic lupus erythematosus (SLE) is the prototypic autoimmune disorder, characterised by auto-antibody production against nuclear antigens. Juvenile-onset systemic lupus erythematosus (JSLE) is a more severe form than the adult-onset disease, with a more balanced gender ratio.
Louise Oni, Colin Thorbinson, Michael W. Beresford   +2 more
openaire   +1 more source

Multicentric Prevalence Study of Anti-P Ribosomal Autoantibodies in Juvenile Onset Systemic Lupus Erythematosus Compared With Adult Onset Systemic Lupus Erythematosus

Reumatología Clínica (English Edition), 2015
To investigate the prevalence and associations with clinical manifestations of anti- P ribosomal antibodies in patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).Clinical and serological data of 30 patients with juvenile-onset SLE (age at onset younger than 16 years old) were compared with data of 92 patients with adult ...
Cecilia N, Pisoni, Sebastián Andrés, Muñoz, Carolina, Carrizo, Micaela, Cosatti, Analía, Álvarez, Diana, Dubinsky, Eleonora, Bresan, Ricardo, Russo, Ezequiel, Borgia, Mercedes, García, Pierina, Sansinanea, María Cristina, Basta, Maria Agustina, D'Amico, Juan Carlos, Barreira, Eliana, Lancioni, Enrique, Soriano, Carmen de, Cunto, Ana, Beron, Alicia, Eimon   +18 more
openaire   +2 more sources