Results 151 to 160 of about 893,284 (261)

Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model. [PDF]

Int J Stem Cells, 2021
Jin X, Hou J, Zheng K, Wei D, Zhang A, Wang S, Mei H, Li C, Cheng L, Sun X.   +9 more
europepmc   +1 more source

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 655-666, September 2026.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source

A Case of Intravascular Diffuse Large B-Cell Lymphoma Initially Suspected as Interstitial Pneumonia Associated With Systemic Scleroderma. [PDF]

J Investig Med High Impact Case Rep, 2021
Oguri T, Sasada S, Aramaki-Sumii Y, Tsuchiya Y, Ishioka K, Takahashi S, Kunieda H, Kimura Y, Seki R, Hirose S, Nakamura M.   +10 more
europepmc   +1 more source

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

JEADV Clinical Practice, Volume 5, Issue 3, Page 917-921, September 2026.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source

Case Report: Scleroderma Renal Crisis Presenting as Thrombotic Microangiopathy

Turkish Journal of Nephrology, 2019
Scleroderma is a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in multiple organs. It can cause thrombotic microangiopathy.
Mehmet Can UĞUR, Ferhat EKİNCİ, Tuğba KARADENİZ, Elif GRAM, Hülya ÇOLAK, Cengiz CEYLAN, Harun AKAR   +6 more
doaj  

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, Volume 270, Issue 1, Page 98-113, September 2026.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen, Samu Luostarinen, Ida Valjus, Julia Vistbacka, Antti Pemmari, Eeva Moilanen   +5 more
wiley   +1 more source

A Hospitalized Patient With Systemic Scleroderma Requiring ICU-Level Care. [PDF]

Cureus
Ghahary D, Goldstein B, Hong L, Maffey M.   +3 more
europepmc   +1 more source

Respiratory Failure in a Rare Case of Juvenile Dermatomyositis - Systemic Scleroderma Overlap Syndrome. [PDF]

Maedica (Bucur), 2020
Popescu NA, Manea D, Capitanescu G, Cinteza E, Ionescu MD, Balgradean M.   +5 more
europepmc   +1 more source