Results 141 to 150 of about 1,679,247 (398)

Influence of FK 506 (tacrolimus) on circulating CD4 ⁺ t cells expressing cd25 and cd45ra antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial [PDF]

, 1994
We have taken the opportunity of a clinical trial of the potential efficacy and safety of FK 506 (tacrolimus) in chronic progressive multiple sclerosis (MS) to examine the influence of this potent new immunosuppressant on circulating T-lymphocytes in an ...
A. W. Thomson, Abu-Elmagd K., B. Eidelman, B. Lemster, Collett D, Eidelman B H., Ellison G W., Emry P., Fung J J., H. R. Rilo, Hafler D A., Hafler D A., Hauser S L., Hintzen R Q., Hofman F M., J. J. Fung, J. Woo, Japanese FK, K. Abu-Elmagd, Kino T., Kurtzke J F, L. L. Huang, Lebranchu Y., Lemster B., Lemster B., McCauley J., McMichael J., Mochizuki M., Mortimoto C, N. Johnson, P. B. Carroll, R. Russell-Hall, Rose L M., Starzl T E., T. E. Starzl, Tamura K., The Multiple Sclerosis Study Group, Thomson A V., Thomson A W, Thomson A W., Thomson A W., Thomson A W., Tocci M J., W. Irish, Woo J., Woo J., Zeevi A.   +46 more
core   +1 more source

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

Nature Communications, 2019
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and vasculopathy. CXCL4 represents an early serum biomarker of severe SSc and likely contributes to inflammation via chemokine signaling pathways, but the exact role of ...
R. Lande, Ernest Y Lee, R. Palazzo, B. Marinari, I. Pietraforte, G. S. Santos, Yves Mattenberger, F. Spadaro, K. Stefanantoni, N. Iannace, A. Dufour, M. Falchi, Manuela Bianco, E. Botti, L. Bianchi, M. Alvarez, V. Riccieri, M. Truchetet, Gerard C L Wong, C. Chizzolini, L. Frasca   +20 more
semanticscholar   +1 more source

Therapy of systemic sclerosis

Reumatismo, 2011
The treatment of the patient with systemic sclerosis has greatly improved in the last ten years, because of two kinds of achievements. A number of drugs have been demonstrated to be active in some disease manifestations like alveolitis, pulmonary hypertension and complicated Raynaud's phenomenon. Some of these drugs namely cyclophosphamide and iloprost
openaire   +5 more sources

CARDIAC ARRHYTHMIA AND CONDUCTION DISTURBANCES IN PATIENTS WITH SYSTEMIC SCLEROSIS

Alʹmanah Kliničeskoj Mediciny, 2016
Aim: To assess prevalence of certain cardiac arrhythmias and conduction disturbances in the Russian population of systemic sclerosis patients using standard 12-lead and 24-hour electrocardiography (ECG); to estimate correlation between cardiac arrhythmia
R. T. Alekperov, E. O. Cheremukhina, D. S. Novikova, L. P. Anan’eva   +3 more
doaj   +1 more source

Increased circulating levels of vitamin D binding protein in MS patients [PDF]

, 2015
Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and ...
Cortese, Antonio, Francisci, Silvia, Gauzzi, Maria Cristina, Gessani, Sandra, Mechelli, Rosella, Millefiorini, Enrico, Purificato, Cristina, Rinaldi, Arturo Ottavio, Salvetti, Marco, Sanseverino, Isabella   +9 more
core   +2 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis

BMC Pulmonary Medicine, 2009
Background The association between systemic sclerosis and pulmonary arterial hypertension (PAH) is well recognized. Vascular endothelial growth factor (VEGF) has been reported to play an important role in pulmonary hypertension.
Sakkas Lazaros, Koutroumpas Athanasios, Ziogas Athanasios, Koutsokera Angela, Kiropoulos Theodoros, Kostikas Konstantinos, Zakynthinos Epaminondas, Papaioannou Andriana I, Gourgoulianis Konstantinos I, Daniil Zoe D   +9 more
doaj   +1 more source

Prevalence, sensitivity and specificity of antibodies against carbamylated proteins in a monocentric cohort of patients with rheumatoid arthritis and other autoimmune rheumatic diseases [PDF]

, 2016
Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity and specificity of anti-CarP compared to ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Mancini, Riccardo, Morello, Francesca, Pecani, Arbi, Pendolino, Monica, Priori, Roberta, Riccieri, Valeria, Sabatinelli, Danilo, Spinelli, FRANCESCA ROMANA, Truglia, Simona, Valesini, Guido, Vomero, Marta   +16 more
core   +1 more source

Cuproptosis Signature Would Reveal the Acute‐Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu, Ruoyu Li, Xinlin Wang, Hui Li, Huiru Hu, Ang Shen, Wenping Zhu, Jiali Pan, Yanmeng Xing, Weiming Xia, Henan Jiao, Di Chen, Lixin Wu, Li Liu, Ju Liu, Bin Yu, Xianzhi Liu, Hongbo Liu   +17 more
wiley   +1 more source

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Nature Communications, 2019
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify ...
E. López-Isac, M. Acosta-Herrera, M. Kerick, S. Assassi, Ansuman T. Satpathy, Jeffrey M. Granja, Maxwell R Mumbach, L. Beretta, C. Simeón, P. Carreira, N. Ortego-Centeno, I. Castellví, L. Bossini‐Castillo, F. Carmona, G. Orozco, N. Hunzelmann, J. Distler, A. Franke, C. Lunardi, G. Moroncini, A. Gabrielli, J. D. de Vries-Bouwstra, C. Wijmenga, B. Koeleman, A. Nordin, L. Padyukov, A. Hoffmann-Vold, B. Lie, S. Proudman, W. Stevens, M. Nikpour, T. Vyse, A. Herrick, Jane Worthington, C. Denton, Y. Allanore, M. Brown, T. Radstake, C. Fonseca, Howard Y. Chang, M. Mayes, Javier Martín   +41 more
semanticscholar   +1 more source