Antinuclear antibodies in systemic sclerosis associated with increased risk of malignancy
Przegląd Dermatologiczny, 2018 Patients with systemic sclerosis are at 1.5–5-fold increased risk of developing malignant diseases. It has been shown that some types of antinuclear antibodies associated with systemic sclerosis may have predictive value for development of malignant ...
Anna Stochmal +3 more
doaj +1 more source
Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. [PDF]
, 2011 OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through ...
Jimenez, Sergio A., Li, zhaodong
core +2 more sources
Current advances in the treatment of systemic sclerosis.
Current opinion in pharmacology (Print), 2022 H. Bukiri, E. Volkmann
semanticscholar +1 more source
Interstitial lung disease associated with systemic sclerosis (SSc-ILD)
Respiratory Research, 2019 BackgroundSystemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death.Main bodyAll patients newly diagnosed with SSc ...
V. Cottin, K. Brown
semanticscholar +1 more source
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
Immunogenetics of Systemic Sclerosis
GenesSystemic sclerosis (SSc) is a rare autoimmune connective tissue disorder characterized by massive fibrosis, vascular damage, and immune imbalance. Advances in rheumatology and immunology over the past two decades have led to a redefinition of systemic sclerosis, shifting from its initial perception as primarily a “hyperfibrotic” state towards a ...
Olga Gumkowska-Sroka +2 more
openaire +3 more sources
Lung function and the response to exercise in systemic sclerosis [PDF]
, 1969 S. Godfrey +2 more
openalex +1 more source
A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing
Advanced Science, EarlyView.This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang +17 more
wiley +1 more source
Cardiorespiratory performance in systemic sclerosis. [PDF]
, 1969 S. Godfrey +2 more
openalex +1 more source
Treatment Algorithms for Systemic Sclerosis According to Experts
Arthritis & Rheumatology, 2018 There is a lack of agreement regarding treatment for many aspects of systemic sclerosis (SSc). We undertook this study to generate SSc treatment algorithms endorsed by a high percentage of SSc experts.
A. Fernández-Codina +2 more
semanticscholar +1 more source