Systemic sclerosis - Open Access .click

Results 191 to 200 of about 293,399 (308)

Sex Disparity in Systemic Sclerosis-Associated Pulmonary Fibrosis. [PDF]

Int J Mol Sci
Galimba AN +4 more
europepmc +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat +14 more
wiley +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

From Silicosis to Systemic Sclerosis: Erasmus Syndrome in a Young Galamseyer-Case Report. [PDF]

Case Rep Dermatol Med
Gyabaah S +7 more
europepmc +1 more source

The American College of Rheumatology Updated Recommended Methods for Development of Disease Classification and Response Criteria

Arthritis &Rheumatology, EarlyView.
Disease classification criteria and response criteria are important tools in the conduct of observational studies and clinical trials for rheumatic diseases. This paper updates methodologic guidance for classification and response criteria funded, developed and/or endorsed by the American College of Rheumatology (ACR), incorporating contemporary ...
Sindhu R. Johnson +4 more
wiley +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi +11 more
wiley +1 more source

Local genetic correlations between systemic sclerosis and common cancer types. [PDF]

PLoS One
Patasova K +4 more
europepmc +1 more source

The nuclear receptor TR4 orchestrates cytoskeletal organization in a Gα12/ROCK‐dependent manner to promote myofibroblast differentiation and tissue fibrosis in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of the testicular receptor 4 (TR4, or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated.
Yun Zhang +16 more
wiley +1 more source

A dynamic vascular-inflammatory-fibrotic loop in systemic sclerosis: an integrative immuno-vascular framework. [PDF]

Front Immunol
Ionitescu RC.
europepmc +1 more source

Integrated Clinical and Proteomic Profiling of CD19 CAR‐T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T‐cell therapy in patients with progressive systemic sclerosis. Methods Patients with progressive systemic sclerosis received CD19 CAR‐T cell therapy and were followed longitudinally for safety, clinical efficacy, immune ...
Chenhan Jia +16 more
wiley +1 more source

scleroderma
interstitial lung disease
epidemiology

diseases of the musculoskeletal system