Results 201 to 210 of about 1,628,316 (351)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Glia, EarlyView.
FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte‐mediated neurotoxicity. FABP7 silencing attenuates NF‐κB‐dependent transcriptional response during endotoxemia. ABSTRACT Fatty acid binding proteins (FABPs) are a family of small proteins involved in fatty acid (FA) subcellular trafficking.
Mariana Bresque, Daniel Esteve, Garret Balmer, Haylee L. Hamilton, Joshua S. Stephany, Mariana Pehar, Marcelo R. Vargas   +6 more
wiley   +1 more source

What Does Iron Mean to an Oligodendrocyte?

Glia, EarlyView.
ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions. The brain has the highest rate of energy consumption, and within the brain, oligodendrocytes have the highest level of oxidative metabolism per volume. Oligodendrocytes also stain the strongest for iron.
Quinn W. Wade, James R. Connor
wiley   +1 more source

Biological hallmarks of systemic sclerosis are present in the skin and serum of patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS). [PDF]

Rheumatology (Oxford)
Ross RL, Caballero-Ruiz B, Clarke EL, Kakkar V, Wasson CW, Mulipa P, De Lorenzis E, Merchant W, Di Donato S, Rindone A, Herrick AL, Denton CP, Riobo-Del Galdo NA, Del Galdo F.   +13 more
europepmc   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Cerebrovascular Involvement in Systemic Sclerosis. [PDF]

ACR Open Rheumatol
Cutolo M, Vojinovic T, Paolino S, Campitiello R, Smith V.   +4 more
europepmc   +1 more source

Systemic Sclerosis and Reflux [PDF]

Ear, Nose & Throat Journal, 2013
Jonathan M. Bock, John J. Petronovich
openaire   +4 more sources

Malignancy in Systemic Sclerosis: A Multicenter Retrospective Study. [PDF]

Biomedicines
Nemes-Tömöri D, Jász DK, Tari D, Bói B, Ágoston-Szabó Á, Szűcs G, Majai GE.   +6 more
europepmc   +1 more source

Systemic sclerosis complicating endometrial adenocarcinoma: A case report. [PDF]

Medicine (Baltimore)
Yan HC, Huang C.
europepmc   +1 more source

Ultrasonographic evaluation of hand and wrist joints in patients with systemic sclerosis. [PDF]

J Scleroderma Relat Disord
Ermancık Z, Yayla ME, İlbay A, Göveç Gıynaş N, Sezer S, Uslu E, Ateş A, Turgay M.   +7 more
europepmc   +1 more source