Results 231 to 240 of about 2,931,663 (352)

Expert viewpoint on endpoints in systemic sclerosis: current and future outlook. [PDF]

RMD Open
Hoffmann-Vold AM, Distler O, Del Galdo F, Distler JH, Allanore Y, Bernstein EJ, Denton CP, Kuwana M, Matucci-Cerinic M, Alves M, Smith V.   +10 more
europepmc   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Shear Wave Elastography for Non-Invasive Assessment of Skin Involvement in Systemic Sclerosis. [PDF]

Diagnostics (Basel)
Liu X, Yin H, Lin W, Jia C, Wu F, Li X, Wu C, Guo R, Lu L, Jiang L.   +9 more
europepmc   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Scoping literature review on applied definitions of very early diagnosis of systemic sclerosis (VEDOSS) and pre-systemic sclerosis in original articles. [PDF]

RMD Open
Lescoat A, Allanore Y, Del Galdo F, Kuwana M, Denton CP, Khanna D, Matucci-Cerinic M, Bellando-Randone S.   +7 more
europepmc   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

Beyond Inflammation: Breaking the Vicious Cycle of Matrix Stiffness and Mechanotransduction in Systemic Sclerosis. [PDF]

Int J Rheum Dis
Cheng TK, Misra DP, Wei JC.
europepmc   +1 more source

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source

Vulvar findings and sexual dysfunction in women with systemic sclerosis. [PDF]

JAAD Int
Mercipinetti M, Delmas-Lanta S, Chaby G, Goeb V, Schmidt J, Reilhac A, Arnault JP.   +6 more
europepmc   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source