Results 251 to 260 of about 2,931,663 (352)

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Osteolysis After Interphalangeal Joint Arthrodesis in Systemic Sclerosis: A Case Series. [PDF]

J Rheumatol
Mathias KR, Grandison J, Lifchez SD, Wigley F.   +3 more
europepmc   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Impact of social deprivation on cancer occurrence and cardiovascular events in systemic sclerosis. [PDF]

Rheumatol Adv Pract
Turnbull A, Tymoszuk U, Pearce FA, Faber BG, Barratt SL, Farrington S, Jeffries-Owen N, Shah AA, Pain C, Denton CP, Pauling JD.   +10 more
europepmc   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Oral and Periodontal Manifestations in Systemic Sclerosis: A Comprehensive Review of Pathophysiology, Clinical Features, and Management Strategies. [PDF]

Oral Health Prev Dent
Meer R.
europepmc   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Mapping and predicting mortality from systemic sclerosis

Annals of the Rheumatic Diseases, 2017
M. Elhai, C. Meune, M. Boubaya, J. Avouac, E. Hachulla, A. Balbir-Gurman, G. Riemekasten, P. Airó, B. Joven, S. Vettori, F. Cozzi, S. Ullman, L. Czirják, M. Tikly, U. Müller-Ladner, P. Caramaschi, O. Distler, F. Iannone, L. Ananieva, R. Hesselstrand, R. Bečvář, A. Gabrielli, N. Damjanov, M. J. Salvador, V. Riccieri, C. Mihai, G. Szücs, U. Walker, N. Hunzelmann, D. Martinović, V. Smith, C. de Souza Müller, C. Montecucco, D. Opris, F. Ingegnoli, P. Vlachoyiannopoulos, B. Stamenkovic, E. Rosato, S. Heitmann, J. Distler, T. Zénone, M. Seidel, A. Vacca, E. De Langhe, S. Novak, M. Cutolo, L. Mouthon, J. Henes, C. Chizzolini, C. V. von Mühlen, K. Solanki, S. Rednic, L. Stamp, B. Anić, Vera Ortiz Santamaría, M. De Santis, Ş. Yavuz, W. Sifuentes-Giraldo, E. Chatelus, J. Štork, J. V. van Laar, E. Loyo, P. García de la Peña Lefebvre, K. Eyerich, V. Cosentino, J. Alegre-Sancho, O. Kowal-Bielecka, G. Rey, M. Matucci-Cerinic, Y. Allanore   +69 more
semanticscholar   +1 more source

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome With Limited Systemic Sclerosis. [PDF]

Cureus
Vallejo Rico CF, Salazar Gonzalez GLA, Reyes Rueda J, Gonzalez Quiroz V, Garay Hernandez JA.   +4 more
europepmc   +1 more source