Results 271 to 280 of about 293,399 (308)
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2009
Systemic sclerosis and its subtypes differ significantly from other diseases in rheumatology and clinical immunology, as the aberrant activation of the immune system does not result in an inflammation-driven destruction but in a progressive matrix synthesis, especially of the skin. Owing to the recently established networks in Germany (DNSS) as well as
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Systemic sclerosis and its subtypes differ significantly from other diseases in rheumatology and clinical immunology, as the aberrant activation of the immune system does not result in an inflammation-driven destruction but in a progressive matrix synthesis, especially of the skin. Owing to the recently established networks in Germany (DNSS) as well as
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The complement system and systemic sclerosis
Immunologic Research, 1993Serum concentrations of the various complement components including the classical and the alternative pathways were determined in 58 control healthy subjects and 80 patients with systemic sclerosis (SSC). The mean concentrations of C1q, C2, C5, C6, C7, C9, and factor B were significantly increased in the SSC patients in comparison to controls, while ...
BENBASSAT C +5 more
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Myopathy in systemic sclerosis
Current Opinion in Rheumatology, 2023Purpose of review Systemic sclerosis associated myopathy (SSc-AM) is a complex, heterogenous disease that is associated with poor outcomes. SSc-AM lacks a clear definition, and continues to be poorly recognized. The purpose of this review is to provide a contemporary overview of the clinical, serological and pathophysiologic ...
Caoilfhionn M, Connolly, Julie J, Paik
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Rheumatic Disease Clinics of North America, 1990
Systemic sclerosis is a disease characterized by several distinctive features. This disease spares children, and its incidence increases steadily with age. Women are affected more than men, especially during childbearing years. Although there is no overall racial predilection, SSc occurs most frequently and severely in young black women.
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Systemic sclerosis is a disease characterized by several distinctive features. This disease spares children, and its incidence increases steadily with age. Women are affected more than men, especially during childbearing years. Although there is no overall racial predilection, SSc occurs most frequently and severely in young black women.
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The Immunogenetics of Systemic Sclerosis
2022Systemic sclerosis (SSc) is a rare disease with a prevalence ranging from 7 to 700 cases per million. Like with most autoimmune diseases, both environmental and genetic factors are involved in the pathogenesis of the SSc. Though the incidence of SSc in the family members of those affected and the concordance rate in twins is very low, inheritance is ...
Begüm Ünlü +4 more
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Immunogenetics of systemic sclerosis
Autoimmunity Reviews, 2011In the field of genetics of SSc, we are currently reaching a period of rapid data production. Several themes are already rising from the first wave of results. First, some genetic variants clearly predispose to multiple autoimmune diseases, thus providing evidence for a shared autoimmune genetic background.
P, Dieudé, C, Boileau, Y, Allanore
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Treatment of systemic sclerosis
Current Opinion in Rheumatology, 1991Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thickening, digital ulcers or ...
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Nutrition in Systemic Sclerosis
Reumatología Clínica (English Edition), 2012Systemic sclerosis is a connective tissue disease characterized by inflammation and fibrosis of multiple organs (skin, gastrointestinal tract, lung, kidney and heart). After the skin, the organ most affected with a frequency of 75 to 90%, the gastrointestinal tract is more often involved.
M A Asunción, Recasens +2 more
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Treatment of systemic sclerosis
Current Opinion in Rheumatology, 1993Guidelines for the conduct of clinical trials in progressive systemic sclerosis have been recommended to determine drug efficacy better. To date, the results of disease-modifying drugs in scleroderma have been disappointing. The treatment of esophagitis has been revolutionized by omeprazole.
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Systemic sclerosis and cryoglobulinemia
Clinical Immunology and Immunopathology, 1976Abstract A systematic survey for cryoglobulinemia was carried out in 20 patients with systemic sclerosis. A mixed cryoglobulin was found in 10 patients. The cryoglobulin always contained IgG and IgM, IgA five times, and C 3 three times. The presence of a cryoglobulin was usually associated with an anti-γ-globulin activity in the serum and in the ...
J M, Husson +4 more
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