Results 281 to 290 of about 293,399 (308)
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Cytokines and systemic sclerosis
Clinics in Dermatology, 1994T he defining pathologic features of systemic sclerosis (SSc) include excessive extracellular matrix deposition and a mononuclear perivascular infiltrate, usually involving both the skin and internal organs and capable of microvascular obliteration. Studies of the pathogenesis of SSc have implicated a role for monocytes, macrophages, T-lymphocytes, the
D M, Fagundus, E C, Leroy
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Current Opinion in Rheumatology, 2007
Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome.A large multicenter study coordinated by the Pediatric Rheumatology European Society has yielded important information on the epidemiology and clinical ...
Zulian F., Martini G.
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Juvenile systemic sclerosis has a variety of clinical manifestations, sometimes different from the adult form. Early recognition, proper classification and treatment may improve the long-term outcome.A large multicenter study coordinated by the Pediatric Rheumatology European Society has yielded important information on the epidemiology and clinical ...
Zulian F., Martini G.
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The genetics of systemic sclerosis
Current Rheumatology Reports, 2002The etiopathogenesis of systemic sclerosis (SSc) is unclear. With no definitive evidence supporting an environmental cause, recent attention has focused on genetic factors. Familial clustering and ethnic influences have been demonstrated. Human leukocyte antigen (HLA) associations exist but are more related to the presence of particular autoantibodies ...
Randall W, Johnson +2 more
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Current Allergy and Asthma Reports, 2015
Systemic sclerosis (SSc) is a rare autoimmune disease characterized by autoantibody production, small-vessel vasculopathy, and skin and other organ fibrosis. The disease is clinically heterogeneous with most patients having some degree of skin sclerosis with varying organ system involvement.
Courtney J, McCray, Maureen D, Mayes
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Systemic sclerosis (SSc) is a rare autoimmune disease characterized by autoantibody production, small-vessel vasculopathy, and skin and other organ fibrosis. The disease is clinically heterogeneous with most patients having some degree of skin sclerosis with varying organ system involvement.
Courtney J, McCray, Maureen D, Mayes
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Microvasculature in Systemic Sclerosis
Rheumatic Disease Clinics of North America, 1990The considerable amount of consistent data obtained with different techniques regarding the nailfold capillary morphology and function in SSc sheds increasing light on the natural history and the different evolutive patterns of SSc microangiopathy. These data also provide a strong support for a nosologic spectrum of entities like SSc, CREST syndrome ...
P H, Carpentier, H R, Maricq
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The Immunobiology of Systemic Sclerosis
Seminars in Arthritis and Rheumatism, 2008Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by vascular damage, autoimmunity, and excessive collagen deposition. Despite advances in disease-specific treatment of other rheumatologic diseases, disease-targeted treatment in SSc continues to be elusive. In this review, our goal was to place the contemporary immunobiology
Y Stephanie, Gu +5 more
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Systemic Sclerosis, Scleroderma
2006Abstract The scleroderma spectrum of disorders includes several diseases that have Raynaud’s phenomenon or skin sclerosis in common, comprising (1) localized cutaneous scleroderma; (2) systemic sclerosis (SSc)—the most important form of scleroderma—limited cutaneous SSc, diffuse cutaneous SSc, and overlap syndromes (with features of ...
Christopher P. Denton, Carol M. Black
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Telangiectases in Systemic Sclerosis
JAMA Dermatology, 2021Rebecca, Jacobson +2 more
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