Results 101 to 110 of about 4,055,022 (317)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Joining and decomposing reaction networks

, 2019
In systems and synthetic biology, much research has focused on the behavior and design of single pathways, while, more recently, experimental efforts have focused on how cross-talk (coupling two or more pathways) or inhibiting molecular function ...
Gross, Elizabeth, Harrington, Heather A, Meshkat, Nicolette, Shiu, Anne   +3 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Topological structures of adiabatic phase for multi-level quantum systems

, 2007
The topological properties of adiabatic gauge fields for multi-level (three-level in particular) quantum systems are studied in detail. Similar to the result that the adiabatic gauge field for SU(2) systems (e.g.
Arvinda, Atiyah M Berndt J, Byrd M, Byrd M, Byrd M, Byrd M, Ercolessi E, Gerdt V Horan R Khvedelidze A Lavelle M McMullan D Palii Y, Jing-Ling Chen, Müller-Hoissen F, Sanders B C, Schlienz J, Scully M O, Slater P B, Xiao-Ting Zhou, Xin Liu, Xiong-Jun Liu, Zheng-Xin Liu   +17 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

ADAPTIVE DECISION SUPPORT SYSTEMS FOR CYBER SECURITY

Сучасні інформаційні системи, 2019
The subject of the research is the principles and models of adaptive decision support systems in cyber security. The purpose is to develop basic principles and models underlying the operation of adaptive decision support systems in the field of ...
Oleksandr Milov
doaj   +1 more source

CSL model checking of Deterministic and Stochastic Petri Nets [PDF]

, 2005
Deterministic and Stochastic Petri Nets (DSPNs) are a widely used high-level formalism for modeling discrete-event systems where events may occur either without consuming time, after a deterministic time, or after an exponentially distributed time.
Haverkort, Boudewijn R., Martinez, José M   +1 more
core   +3 more sources

Level and Eigenfunction Statistics in Billiards with Surface Scattering

, 2000
Statistical properties of billiards with diffusive boundary scattering are investigated by means of the supersymmetric sigma-model in a formulation appropriate for chaotic ballistic systems.
A. A. Abrikosov, A. Altland, A. Altland, A. Altland, A. D. Mirlin, A. D. Mirlin, A. D. Mirlin, A. D. Mirlin, A. G. Aronov, A. Kudrolli, A. M. Ozorio de Almeida, A. Szafer, A. V. Andreev, A. V. Andreev, A. V. Andreev, B. A. Muzykantskii, B. A. Muzykantskii, B. A. Muzykantskii, B. D. Simons, B. L. Altshuler, C. W. J. Beenakker, C. W. J. Beenakker, D. E. Khmelnitskii, D. Taras-Semchuk, E. B. Bogomolny, E. Cuevas, E. Louis, E. Louis, E. Louis, F. Borgonovi, H. Alt, I. L. Aleiner, I. L. Aleiner, J. Goldberg, J. Stein, K. B. Efetov, K. Fuchs, K. M. Frahm, K. M. Frahm, K. M. Frahm, K. V. Samokhin, L. P. Kouwenhoven, M. L. Mehta, M. Srednicki, M. V. Berry, M. V. Berry, M. V. Berry, O. Agam, O. Agam, P. Wölfle, R. E. Prange, S. Bjørnholm, S. Hortikar, T. Guhr, V. E. Kravtsov, V. E. Kravtsov, V. I. Fal’ko, V. I. Fal’ko, V. I. Okulov, V. M. Apel, V. N. Prigodin, V. N. Prigodin, V. N. Prigodin, V. Tripathi, Y. V. Fyodorov, Ya. M. Blanter, Ya. M. Blanter, Ya. M. Blanter, Ya. M. Blanter, Yu. N. Ovchinnikov   +69 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source