Results 101 to 110 of about 4,082,982 (293)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
ADAPTIVE DECISION SUPPORT SYSTEMS FOR CYBER SECURITY
Сучасні інформаційні системи, 2019 The subject of the research is the principles and models of adaptive decision support systems in cyber security. The purpose is to develop basic principles and models underlying the operation of adaptive decision support systems in the field of ...
Oleksandr Milov
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
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VehiclesDesigning strongly interacting vehicle components in the early development phase is challenging because numerous requirements, uncertainties, and conflicting objectives significantly limit feasible design solutions.
Sebastian Wagner, Dieter Schramm
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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RUDN Journal of Ecology and Life Safety, 2010 At healthy calves of a dairy feed the increase of functional activity anticoagulative and fibrinolysis takes place. It conducts to to maintenance on an optimum level of liquid properties of blood, her flow characteristics of properties, providing a ...
S Y Zavalishina
doaj
Quasinormal modes and complexity in saddle-dominated SU(N) spin systems
Journal of High Energy PhysicsWe study SU(N) spin systems that mimic the behavior of particles in N-dimensional de Sitter space for N = 2, 3. Their Hamiltonians describe a dynamical system with hyperbolic fixed points, leading to emergent quasinormal modes at the quantum level. These
Sergio E. Aguilar-Gutierrez +3 more
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In Vitro Production and Screening of DNA Polymerase η Mutants for Catalytic Diversity
BioTechniques, 2002 Mutant DNA polymerases have become an increasingly important tool in biotechnology. The ability to examine the activity and specific properties of enzymes has a crucial role in the characterization of the enzyme.
Eitan Glick +2 more
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source