Results 111 to 120 of about 4,055,022 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Integrable random matrix ensembles

open access: yes, 2011
We propose new classes of random matrix ensembles whose statistical properties are intermediate between statistics of Wigner-Dyson random matrices and Poisson statistics.
Bogomolny, E., Giraud, O., Schmit, C.
core   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

In Vitro Production and Screening of DNA Polymerase η Mutants for Catalytic Diversity

open access: yesBioTechniques, 2002
Mutant DNA polymerases have become an increasingly important tool in biotechnology. The ability to examine the activity and specific properties of enzymes has a crucial role in the characterization of the enzyme.
Eitan Glick   +2 more
doaj   +1 more source

Chaos Driven Decay of Nuclear Giant Resonances: Route to Quantum Self-Organization

open access: yes, 1993
The influence of background states with increasing level of complexity on the strength distribution of the isoscalar and isovector giant quadrupole resonance in $^{40}$Ca is studied.
A. Bialas   +33 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

STRUCTURAL APPROACH FOR NUMERICAL INTERNAL STRAIN MODELLING OF CONGLOMERATE STRUCTURES

open access: yesArchitecture and Engineering, 2017
The paper defines the principles for structure-simulation modelling of conglomerate material properties by an example of cement compositions. The constitutive essence of the principles consists in generation of hierarchical models of individual ...
Aleksey Kharitonov
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Quasinormal modes and complexity in saddle-dominated SU(N) spin systems

open access: yesJournal of High Energy Physics
We study SU(N) spin systems that mimic the behavior of particles in N-dimensional de Sitter space for N = 2, 3. Their Hamiltonians describe a dynamical system with hyperbolic fixed points, leading to emergent quasinormal modes at the quantum level. These
Sergio E. Aguilar-Gutierrez   +3 more
doaj   +1 more source

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