Results 141 to 150 of about 14,311,112 (298)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

CGIAR Research Program on Dryland Systems Second day_photo 1

open access: yes, 2016
CGIAR Research Program on Dryland Systems Second day _ photo
Dryland Systems, CRP
core  

System of Systems Characteristics in Production System Engineering.

open access: yes, 2009
This thesis presents a systems view of production, where production systems are compared and contrasted with other large and complex systems, commonly labeled System of Systems (SoS). The rationale for this approach lies in the evolution of production systems towards being holistic, sustainable, and agile; which increases the need for an improved ...
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

CGIAR Research Program on Dryland Systems Second day_photo 2

open access: yes, 2016
CGIAR Research Program on Dryland Systems Second day_photo
Dryland Systems, CRP
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

2017 CPES Annual Report

open access: yes, 2017
In its effort to develop power processing systems to take electricity to the next step, CPES has cultivated research expertise encompassing five technology areas: (1) power conversion technologies and architectures; (2) power electronics components; (3 ...
Center for Power Electronics Systems   +1 more
core  

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