Results 161 to 170 of about 13,108,811 (339)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Global determinants of cervical cancer outcomes: a health systems analysis. [PDF]

BMJ Oncol
Go AE, Feliciano EJG, Martinez J, Ho FDV, Wu JF, Willmann J, Lapen K, Hugo H, Jeong Y, Singh A, Haylock AB, Shah N, Robredo JPG, Eala MAB, Patel RK, Chen J, Cabaero MLL, Tawfiles D, Venkateswaran S, Tan AKNG, Gyawali B, Moraes FY, Iyengar P, Lee NY, Mango VL, Taunk NK, Magsanoc-Alikpala MJK, Kingham TP, Dee EC.   +28 more
europepmc   +1 more source

Systems analysis of human innate immunity in COVID-19. [PDF]

Semin Immunol, 2023
Müller S, Schultze JL.
europepmc   +1 more source

The Parkes Multibeam Pulsar Survey: I. Observing and Data Analysis Systems, Discovery and Timing of 100 Pulsars

, 2001
R. N. Manchester, A. G. Lyne, F. Camilo, J. F. Bell, V. M. Kaspi, N. D’Amico, N. P. F. McKay, F. Crawford, I. H. Stairs, Andrea Possenti, M. Krämer, D. C. Sheppard   +11 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Systems Analysis of miRNA-Mediated Host Regulatory Response in HPV-Associated Cervical Malignancy. [PDF]

Comput Struct Biotechnol J
Khan I, Suneesh NS, Harshithkumar R, More A, Nandi SS, Khan AA, Mukherjee A.   +6 more
europepmc   +1 more source

Single Scale Analysis of Many Fermion Systems. Part 3: Sectorized Norms [PDF]

, 2002
Joel Feldman, Horst Knoerrer, Eugene Trubowitz   +2 more
openalex   +1 more source

Decision letter for "Performance of intermittently scanned continuous glucose monitoring ( isCGM ) systems in people with type 1 diabetes: a pooled analysis"

, 2021

openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

AI readiness, STEM education, economic growth, and climate transition in China: a long-run systems analysis. [PDF]

Sci Rep
Liu S, Xu M, Xiang X.
europepmc   +1 more source