Results 161 to 170 of about 34,801,835 (296)

Observed Maternal Positive Affect Responsivity Prospectively Predicts Lower Internalizing Problems in Toddlers of Mothers With Depression: A Dynamic Systems Analysis. [PDF]

Res Child Adolesc Psychopathol
Griffith JM, Harrington B, Taraban L, Forbes EE, Morgan JK.   +4 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Systems analysis reveals alternate metabolic states adopted by <i>Mycobacterium tuberculosis</i> across species. [PDF]

mSphere
Padilla-Gomez J, McGinn R, De Andrade V, Liang Y, Libby K, Ni HM, Ringel AE, Evavold CL, Bryson BD.   +8 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Global determinants of cervical cancer outcomes: a health systems analysis. [PDF]

BMJ Oncol
Go AE, Feliciano EJG, Martinez J, Ho FDV, Wu JF, Willmann J, Lapen K, Hugo H, Jeong Y, Singh A, Haylock AB, Shah N, Robredo JPG, Eala MAB, Patel RK, Chen J, Cabaero MLL, Tawfiles D, Venkateswaran S, Tan AKNG, Gyawali B, Moraes FY, Iyengar P, Lee NY, Mango VL, Taunk NK, Magsanoc-Alikpala MJK, Kingham TP, Dee EC.   +28 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Five-layer systems analysis of <i>Leishmania</i> stage differentiation reveals an essential role for protein degradation in parasite development. [PDF]

Elife
Pescher P, Douché T, Giai Gianetto Q, Druart K, Kovářová J, Li B, Cokelaer T, Rajan KS, Piel L, Besse C, Boland A, Deleuze JF, Matondo M, Barrett MP, Michaeli S, Späth GF.   +15 more
europepmc   +1 more source

Advancing Systems Analysis Program

ASA advances systems analysis as a meta-level approach to understand and govern complex socio-environmental systems. The overall objective is to increase realism, relevance, and agility of systems analysis. How? By harvesting new opportunities provided,
Rovenskaya, E.
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Systems Analysis of miRNA-Mediated Host Regulatory Response in HPV-Associated Cervical Malignancy. [PDF]

Comput Struct Biotechnol J
Khan I, Suneesh NS, Harshithkumar R, More A, Nandi SS, Khan AA, Mukherjee A.   +6 more
europepmc   +1 more source