Results 141 to 150 of about 32,758,152 (295)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Reimagining public-private partnerships for primary health care in Africa: a governance and systems analysis of emerging models in Botswana. [PDF]

Front Public Health
Seleke TL.
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Health Systems Analysis of Global Head and Neck Cancer Outcomes. [PDF]

Laryngoscope
Dee EC, Go AE, Feliciano EJG, Wu JF, Willmann J, Lapen K, Treechairusame T, Patel MS, Ranganathan S, Hammond A, Wu Y, Singh A, Wong AM, Jacomina LE, Ma J, Iyengar P, Estilo CL, Kingham TP, Lee NY.   +18 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Sociotechnical-systems analysis of IoT-AI convergence in cosmetic health. [PDF]

Front Med (Lausanne)
Makhseed A, Arian H, Shuaib A.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Peak Analysis System [PDF]

Science, 1973
openaire   +2 more sources

System analysis in vision [PDF]

Eye, 1998
L Henk van der Tweel, Dik Reits, H Spekreijse   +2 more
openaire   +2 more sources

Observed Maternal Positive Affect Responsivity Prospectively Predicts Lower Internalizing Problems in Toddlers of Mothers With Depression: A Dynamic Systems Analysis. [PDF]

Res Child Adolesc Psychopathol
Griffith JM, Harrington B, Taraban L, Forbes EE, Morgan JK.   +4 more
europepmc   +1 more source