Results 131 to 140 of about 3,795,802 (269)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effectiveness of the Systems Analysis and Improvement Approach to optimise outpatient mental, neurological, and substance-use disorder treatment cascades in Mozambique: a cluster-randomised trial. [PDF]

Lancet Psychiatry
Cumbe VFJ, Muanido A, Turner M, Jala JN, Armando EE, Faduque F, Xerinda ER, Sherr K, Flaherty BP, Sharma M, Wagenaar BH.   +10 more
europepmc   +1 more source

Systems analysis of human innate immunity in COVID-19. [PDF]

Semin Immunol, 2023
Müller S, Schultze JL.
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The breast cancer risk assessment pathway in England: a systems analysis of current challenges and ways to improve. [PDF]

Br J Cancer
Valasaki M, Taylor LC, Woof VG, Howell SJ, Tischkowitz M, Antoniou AC, Archer S, French DP, Usher-Smith JA.   +8 more
europepmc   +1 more source

Editorial: Virtual patients and digital twins in the systems analysis of drug discovery and development. [PDF]

Front Syst Biol, 2023
Zhao C, He H, Ma H.
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Author Correction: An assessment of energy system transformation pathways to achieve net-zero carbon dioxide emissions in Switzerland

Communications Earth & Environment, 2023
Evangelos Panos, Ramachandran Kannan, Stefan Hirschberg, Tom Kober   +3 more
doaj   +1 more source

Correction: Study protocol for the: HIV enhanced access testing in emergency department program using a systems analysis and improvement approach (HEATED-SAIA) cluster randomized trial. [PDF]

Implement Sci Commun
Aluisio AR, Loevinsohn G, Chondo E, Nderitu A, Bruba M, Adam A, Baird J, Galárraga O, Wilson-Barthes M, Sarker M, Mandaliya K, Kinuthia J, Bosire R, Wachira B, Gross Z, Cherutich P, Wanje G, McClelland RS, Eastment MC.   +18 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source