Complex biological systems analysis and deep learning for prognostic prediction of esophageal squamous cell carcinoma. [PDF]
iScienceChang Y, Zhang W.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Cross-species systems analysis distinguishes inflammatory remodeling from primary mucus secretory failure in inflammatory bowel disease. [PDF]
Front ImmunolXhumari J +3 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Identification of circadian-regulated genes for enhancing acidic soil tolerance in rice through integrative transcriptomic and systems analysis. [PDF]
Sci RepRoy A, Pandey DM, Dwivedi A.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
AI readiness, STEM education, economic growth, and climate transition in China: a long-run systems analysis. [PDF]
Sci RepLiu S, Xu M, Xiang X.
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Unveiling the immoral ramp feature of dissolved oxygen signals with dynamical systems analysis: perspectives for robust soft-sensor development. [PDF]
Sci RepSchneider MY, Torfs E, Carbajal JP.
europepmc +1 more source
A structured approach to applying systems analysis methods for examining implementation mechanisms. [PDF]
Implement Sci Commun, 2023 Kim B +5 more
europepmc +1 more source