Results 121 to 130 of about 20,790,490 (298)
Control Engineering and Management Systems
Measurement + Control, 1969 V. A. J. Gifford DLC, CEng, MIProdE, FIWSP, MBIM
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Municipal waste management structural analysis
Business: Theory and Practice, 2010 Municipal waste management system – a complex, dynamic system, characterized by large volumes of waste generated, waste biodiversity and different system participants. The paper presents results of municipal waste management structural analysis.
Juozas Bivainis, Viktorija Podgaiskytė
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Travaux de l'Institut de Speologie Emile Racovitza, 2019 In this first note, we present the taxonomic position and the differential diagnosis of the family Trichoniscidae. In our opinion from the common ancestor of Oniscidea two lineages evolved: a lineage evolved toward the complete disappearance of the ...
IONEL TABACARU, ANDREI GIURGINCA
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Air Force Systems Command Technical Documentary Report 61-453
, 1961 Report discussing a study initiated to investigate and apply techniques of microminiaturization to circuits designed for high reliability performance with two goals: (1) to develop ultra-reliability design techniques in communication equipment, and (2 ...
Anderson, George +1 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Capacity development for agriculture innovation: A practitioners’ guidebook to a systems approach
Also known as CD4AIS. This interactive guidebook brings together tools and resources to help practitioners design and implement capacity development activities with an innovation systems approach in mind.
Wageningen University & Research Centre +2 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source