Results 131 to 140 of about 20,790,490 (298)
Systems Engineering Thesis Research Guide [PDF]
, 2013 Version 1.0This guide has been prepared for Systems Engineering (SE) students to assist them in completing the Master’s thesis. The guide focuses on the preparation, the proposal and the research element of the project, describes the roles and ...
Systems Engineering Department +1 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Preliminares [ISCRAM-Med 2016. Third International Conference on Information Systems for Crisis Response and Management in Mediterranean Countries] [PDF]
, 2016 Poster Papers of ISCRAM-Med 2016 - Third International Conference on Information Systems for Crisis Response and Management in Mediterranean Countries. October 26-28, 2016.
UC3M. Interactive Systems Group
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Selection factors determining the Hybrid Approach: A Benchmark Study
, 2020 The choice of methodology for information system development (ISD) is a significant question faced by information systems (IS) professionals. A sizable body of research details the agile and traditional approaches independently.
Tuxworth, Gervase +2 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
UTILIZING A MODEL-BASED SYSTEMS ENGINEERING APPROACH TO DEVELOP A COMBAT SYSTEM PRODUCT LINE [PDF]
, 2018 Current U.S. Navy combat system suites are ship class dependent. There are a variety of configurations that include sensors, weapons, and system interfaces to accomplish similar goals.
Hall, Robert
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