Results 61 to 70 of about 11,138,963 (294)

The BigDAWG polystore system and architecture [PDF]

2016 IEEE High Performance Extreme Computing Conference (HPEC), 2016
Organizations are often faced with the challenge of providing data management solutions for large, heterogenous datasets that may have different underlying data and programming models. For example, a medical dataset may have unstructured text, relational data, time series waveforms and imagery.
Vijay Gadepally, Peinan Chen, Jennie Duggan, Aaron J. Elmore, Brandon Haynes, Jeremy Kepner, Samuel Madden 0001, Tim Mattson, Michael Stonebraker   +8 more
openaire   +5 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Revisiting the Relationship between Software Architecture and Requirements : the case of Dynamically Adaptive Systems [PDF]

, 2009
This paper revisits the relationship between software architecture and requirements focusing on the case of selfadaptive systems. The authors present their view of the state-of-the-art, including their own work, on both areas and their contribution ...
Sawyer, Peter, Grace, P., Bencomo, Nelly
core   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An information-driven architecture for cognitive systems research [PDF]

, 2008
Wrede S. An information-driven architecture for cognitive systems research. Bielefeld (Germany): Bielefeld University; 2008.With computer science more and more leaving the traits of solitary algorithms and distinct disciplines towards complex intelligent
Wrede, Sebastian ; https://orcid.org/
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Zone adaptive fuel mapping for high resolution wildfire spread forecasting

Scientific Reports
Extreme wildfire events (EWE), although a rare natural hazard, account for a substantial portion of global wildfire damage, requiring proactive anticipation and mitigation due to their increasing occurrence.
Paula Sánchez, Irene González, Carlos Carrillo, Ana Cortés, Remo Suppi, Tomàs Margalef   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source