Results 201 to 210 of about 1,150,837 (304)

Systems Biology: The Big Picture [PDF]

, 2004
Angela Spivey
openalex   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

New insights into translational research in Alzheimer's disease guided by artificial intelligence, computational and systems biology. [PDF]

Acta Pharm Sin B
Jiang S, Tian Z, Yang Y, Li X, Zhou F, Cheng J, Lyu J, Gao T, Zhang P, Han H, Tong Z.   +10 more
europepmc   +1 more source

Plastic based microfluidic systems and their applications in biology. [PDF]

, 2002
Palaniappan Sethu
openalex  

Apomixis inAchnanthes(Bacillariophyceae); development of a model system for diatom reproductive biology [PDF]

, 2004
Koen Sabbe, Victor A. Chepurnov, Wim Vyverman, David G. Mann   +3 more
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Identifying Molecular Determinants and Therapeutic Targets in Luminal B Breast Cancer: A Systems Biology Approach. [PDF]

Iran J Pathol
Saeidi Y, Ghorbani M, Najafi A, Moosazadeh Moghaddam M.   +3 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment. [PDF]

PLoS One
Sanami S, Aghaamoo S, Ahmad S, Fazli A, Mansouri B, Nobre Oliveira JI, Rahmanian M.   +6 more
europepmc   +1 more source

High throughput instruments, methods, and informatics for systems biology.

, 2003
Michael B. Sinclair, Jim Cowie, Mark Van Benthem, Brian Wylie, George S. Davidson, David M. Haaland, Jerilyn A. Timlin, Anthony D. Aragon, Michael R. Keenan, Kevin W. Boyack, Edward V. Thomas, Margaret Werner‐Washburne, Mónica Mosquera‐Caro, Michael J. Martinez, Shawn Martin, Cheryl L. Willman   +15 more
openalex   +1 more source