Results 221 to 230 of about 12,579,596 (265)

Integrating AI, mechanistic modelling and network approaches in systems biology for translational research. [PDF]

NPJ Syst Biol Appl
Lai X, Tang J.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Determining parameter impact in systems biology models via sensitivity analysis: a comparative approach. [PDF]

NPJ Syst Biol Appl
Gasior KI.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Roadmap for the Future of Systems Biology in Cancer Research. [PDF]

Cancer Res
Wiley HS, Lopez CF, Rodin AS, Rockne RC, Yankeelov TE, Sauro HM, Hassan G, Prabhakaran S, Demir E, Hu M, Fuxman Bass J, Luddy KA, Newman H, Mochel JP, Costello JC, Xing J, Afify SM, Acar A, Haden Gephart M, Feng S, Banks O, Banerjee J, Clayton A, Hill DE, Sweis RF, Umeh-Garcia MC, Su Y, Meyer AS.   +27 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

AI-Augmented Multi-Omics for Abiotic Stress Responses: A New Frontier in Plant Hormone Systems Biology. [PDF]

Plants (Basel)
Zhang Y, Cao X, Yang L, Chen J, Hwarari D.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Uncovering combination therapies for immune-mediated inflammatory diseases through systems biology analysis on longitudinal patient data. [PDF]

Cell Rep Med
Martínez-Mateu SH, Guillén Y, Angelats E, López-Lasanta MA, Madonna S, Jiménez-Gracia L, Rodriguez-Nunez I, Álvarez-Errico D, Aterido A, Tortosa R, Ruiz M, Serra P, Cañete JD, Carrascosa JM, Domènech E, Gisbert JP, Tornero J, IMID-Consortium, Siegmund B, Girolomoni G, Choy EHS, Myers RM, Heyn H, Santamaria P, Marsal S, Julià A.   +25 more
europepmc   +1 more source